Document Detail

Elevated nicotine levels in patients undergoing hemodialysis. A role in cardiovascular mortality and morbidity?
MedLine Citation:
PMID:  6695947     Owner:  NLM     Status:  MEDLINE    
The incidence of cardiovascular disease in patients with end-stage renal disease undergoing long-term maintenance hemodialysis is excessively high. The reason for this excess morbidity and mortality has remained unclear. Cigarette smoking is one factor that has been associated with increased cardiovascular risk. To learn more about the effects of tobacco smoking in these patients, nicotine levels were assayed in the serum of 10 patients with end-stage renal disease undergoing maintenance hemodialysis. Specimens were obtained before and after smoking one cigarette and following dialysis or an equivalent period in control subjects. Serum nicotine levels (+/-SEM) in control subjects measured 19.0 +/- 7.2 ng/ml initially, 36.1 +/- 8.2 ng/ml after smoking, and 9.3 +/- 3.5 ng/ml after a period of 4.35 hours. These compare with respective values of 76.6 +/- 16.8 ng/ml (p less than 0.004), 132.9 +/- 19.7 ng/ml (p less than 0.001), and 51.9 +/- 10.5 ng/ml (p less than 0.001) in patients undergoing hemodialysis. These data demonstrate markedly higher nicotine levels in hemodialysis patients compared with control subjects, which may have serious implications regarding morbidity and mortality.
R J Perry; W Griffiths; P Dextraze; R J Solomon; W M Trebbin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  76     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-03-09     Completed Date:  1984-03-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  241-6     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiovascular Diseases / etiology
Kidney Failure, Chronic / blood*,  complications,  therapy
Middle Aged
Nicotine / blood*
Peritoneal Dialysis, Continuous Ambulatory
Renal Dialysis*
Reg. No./Substance:

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