Document Detail

Elevated neutrophil respiratory burst activity in essential hypertensive patients.
MedLine Citation:
PMID:  20471005     Owner:  NLM     Status:  MEDLINE    
Neutrophils play a significant role in maintaining the integrity of innate immunity via their potent respiratory burst activity. However, the uncontrolled activation of respiratory burst in neutrophils also attributes to chronic diseases such as primary hypertension and atherosclerosis. In our study, we have investigated the activation of respiratory burst function of neutrophils harvested from essential hypertensive patients. In the presence of stimuli PMA and opsonized zymosan (OZ), hypertensive patients' neutrophils secrete significantly higher amount of superoxide anions compared to normotensive control. Although the magnitude of activation varies between both groups, yet the kinetics of activation is similar. When normotensive control's neutrophils were pre-treated with hypertensive serum, the cells failed to migrate toward fMLP which indicates the impairment of the migration property. In conclusion, the respiratory burst activity of neutrophils is affected by hypertension and their elevated superoxide anions production could be an aggravating factor in hypertension-related complication.
Rajesh Ramasamy; Maryam Maqbool; Abdul Latiff Mohamed; Rahim Md Noah
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-18
Journal Detail:
Title:  Cellular immunology     Volume:  263     ISSN:  1090-2163     ISO Abbreviation:  Cell. Immunol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-4     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia.
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MeSH Terms
Cell Migration Inhibition / immunology
Neutrophils / immunology*
Reactive Oxygen Species / blood
Reference Standards
Respiratory Burst* / immunology
Venous Pressure
Reg. No./Substance:
0/Reactive Oxygen Species

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