Document Detail

Elevated neutrophil elastase and acrolein-protein adducts are associated with W256 regression.
MedLine Citation:
PMID:  23039888     Owner:  NLM     Status:  MEDLINE    
The involvement of granulocytes in immune response against cancer is not well understood. Depending on the cytokine milieu in which they act and on their oxidative burst, granulocytes may play either an inhibitory or stimulatory role in tumour growth. Unsaturated fatty acids, essential components of cellular membranes and storage lipids, are susceptible to granulocyte-derived reactive oxygen species (ROS). ROS can induce lipid peroxidation (LPO) resulting in the destruction of biomembranes. Thus, murine W256 tumour progressing and tumour regressing animal models were used to study the involvement of plasma inflammatory mediators and oxidative burst of circulating granulocytes in malignant destruction and detrimental tumour growth. The involvement of LPO-derived aldehydes (i.e. acrolein, 4-hydroxy-2-nonenal and malondialdehyde) and myeloperoxidase (MPO) appearance in the granulocyte anti-cancer response were further evaluated. The results obtained revealed a significant increase in neutrophil elastase in animals with regressing tumour. Furthermore, the presence of MPO in tumour microenvironment was accompanied by the formation of acrolein only 5 h after tumour transplantation and its presence increased during tumour regression. Later, at an early stage of tumour regression, the presence of other LPO-derived aldehydes were also observed. The results obtained suggest that elevated neutrophil elastase and initiation of LPO may play an important role in the tumour development leading to tumour regression.
M Jaganjac; M Poljak-Blazi; R J Schaur; K Zarkovic; S Borovic; A Cipak; M Cindric; K Uchida; G Waeg; N Zarkovic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  170     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-03-18     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  178-85     Citation Subset:  IM    
Copyright Information:
© 2012 British Society for Immunology.
Department of Molecular Medicine, Rudjer Boskovic Institute Department of Pathology, Medical Faculty, University of Zagreb, Clinical Hospital Centre Zagreb, Zagreb, Croatia.
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MeSH Terms
Acrolein / immunology,  metabolism*
Aldehydes / immunology,  metabolism
Cell Membrane / immunology,  metabolism,  physiology
Disease Progression
Fatty Acids, Unsaturated / immunology,  metabolism
Granulocytes / immunology*,  metabolism*
Inflammation / immunology,  metabolism,  pathology
Leukocyte Elastase / immunology,  metabolism*
Lipid Peroxidation / immunology,  physiology
Malondialdehyde / immunology,  metabolism
Rats, Sprague-Dawley
Rats, Wistar
Reactive Oxygen Species / immunology,  metabolism
Respiratory Burst / immunology,  physiology
Tumor Microenvironment / immunology*,  physiology
Reg. No./Substance:
0/Aldehydes; 0/Fatty Acids, Unsaturated; 0/Reactive Oxygen Species; 107-02-8/Acrolein; 542-78-9/Malondialdehyde; EC Elastase

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