Document Detail


Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting.
MedLine Citation:
PMID:  24353178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The recent discovery of betatrophin, a protein secreted by the liver and white adipose tissue in conditions of insulin resistance and shown to dramatically stimulate replication of mouse insulin-producing β-cells, has raised high hopes for the rapid development of a novel therapeutic approach for the treatment of diabetes. At present, however, the effects of betatrophin on human β-cells are not known. Here we use administration of the insulin receptor antagonist S961, shown to increase betatrophin gene expression and stimulate β-cell replication in mice, to test its effect on human β-cells. Although mouse β-cells, in their normal location in the pancreas or when transplanted under the kidney capsule, respond with a dramatic increase in β-cell DNA replication, human β-cells are completely unresponsive. These results put into question whether betatrophin can be developed as a therapeutic approach for treating human diabetes.
Authors:
Yang Jiao; John Le Lay; Ming Yu; Ali Naji; Klaus H Kaestner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-12-18
Journal Detail:
Title:  Diabetes     Volume:  63     ISSN:  1939-327X     ISO Abbreviation:  Diabetes     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-03-21     Completed Date:  2014-08-06     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1283-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Cell Proliferation / drug effects*
Child, Preschool
Female
Humans
Insulin-Secreting Cells / drug effects,  physiology*
Islets of Langerhans Transplantation
Male
Mice
Mice, Inbred NOD
Mice, SCID
Middle Aged
Peptide Hormones / biosynthesis*
Peptides / pharmacology
Receptor, Insulin / antagonists & inhibitors
Transplantation, Heterologous
Grant Support
ID/Acronym/Agency:
P30 CA016520/CA/NCI NIH HHS; R01-DK-088383/DK/NIDDK NIH HHS; U01-DK-070430/DK/NIDDK NIH HHS; U01-DK-089529/DK/NIDDK NIH HHS; U42-RR0-06042/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Peptide Hormones; 0/Peptides; 0/S961 peptide; 0/lipasin protein, mouse; EC 2.7.10.1/Receptor, Insulin
Comments/Corrections
Comment In:
Diabetes. 2014 Apr;63(4):1198-9   [PMID:  24651805 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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