| Elevated micronuclei frequency in type 2 diabetes with high glycosylated hemoglobin. | |
| | |
MedLine Citation:
|
PMID: 22078074 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIM: The role of oxidative damage to DNA due to hyperglycemia is well known. In the current study we have evaluated the induction of micronuclei due to increased glycosylation in type 2 diabetes. METHODS: Forty-nine subjects divided into two groups of normoglycemic controls and type 2 diabetic cases were recruited in the study. Whole blood was cultured and micronuclei were scored in all the cases. This was correlated with age, sex, blood glucose levels and glycosylated hemoglobin. RESULTS: Age and sex matched diabetic patients had an increased micronuclei frequency in response to elevated glycosylation of hemoglobin (R(2)=0.229, p=0.037) compared to normoglycemic subjects. CONCLUSION: The increased glycosylation seems to induce oxidative damage in the DNA of the diabetic patients, which manifests as an increased micronuclei frequency. This has a potential to be used as a biomarker for subsequent diabetic complications. |
| | |
Authors:
|
Suresh K G Shettigar; C Shailaja; Ratnakar K Kulkarni |
Related Documents
:
|
21642764 - Effects of chronic sr-lanreotide treatment on igf system and metabolic parameters in ac... 12643194 - Current controversies in the mechanisms and treatment of gestational diabetes. 17014924 - Transforming growth factor-beta 1 levels in women with prior history of gestational dia... 9674904 - Epidemiological analysis of outcomes of pregnancy in gestational diabetic mothers. 19368094 - Incidence of type 1 diabetes mellitus and associated complications among children and y... 20665664 - Hepatic expression profiling shows involvement of pkc epsilon, dgk eta, tnfaip, and rho... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-9 |
Journal Detail:
|
Title: Diabetes research and clinical practice Volume: - ISSN: 1872-8227 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Cytogenetics and Molecular Genetics Section, Pathology Unit, Medical Division, BARC Hospital, Anushaktinagar, Mumbai 400094, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolic syndrome in adult cancer survivors: A meta-analysis.
Next Document: Detection of benzo(a)pyrene photodegradation products using DNA electrochemical sensors.