Document Detail

Elevated maternal serum alpha-fetoprotein levels and maternal risk factors. Their association with pregnancy complications.
MedLine Citation:
PMID:  1373447     Owner:  NLM     Status:  MEDLINE    
Maternal serum alpha-fetoprotein (MS-AFP) screening programs identify a population of pregnant women with elevated MS-AFP values. When the levels are unassociated with a fetal anomaly, those women have a high incidence of pregnancy complications. Such patients were compared to a population with normal MS-AFP values to determine the incidence of historical risk factors and to ascertain if their presence affected the rate of pregnancy complications. A total of 358 patients were followed prospectively, 23 with elevated MS-AFP levels and 335 with normal levels (control group). Historical risk factors were more frequent in the patients with elevated MS-AFP levels. There was a fourfold increase in the rate of pregnancy complications when a patient had both risk factors and elevated MS-AFP levels as compared with elevated MS-AFP levels alone. In the control group, patients with known risk factors experienced twice the incidence of pregnancy complications as did patients with no risk factors. Using multiple logistic regression analysis, elevated MS-AFP levels were shown to be an independent variable in the risk assessment. The results of this study have wide application in the counseling and follow-up of patients identified by MS-AFP screening programs.
E L Capeless; P C Kelleher; C P Walters
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  37     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-21     Completed Date:  1992-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Medical Center Hospital of Vermont, Burlington 05401.
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MeSH Terms
Hospitals, University
Logistic Models
Mass Screening / methods,  standards
Medical History Taking
Pregnancy Complications / blood,  epidemiology*,  prevention & control
Prospective Studies
Risk Factors
Sensitivity and Specificity
Vermont / epidemiology
alpha-Fetoproteins / analysis*
Reg. No./Substance:

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