| Elevated maternal serum alpha-fetoprotein levels and maternal risk factors. Their association with pregnancy complications. | |
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MedLine Citation:
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PMID: 1373447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal serum alpha-fetoprotein (MS-AFP) screening programs identify a population of pregnant women with elevated MS-AFP values. When the levels are unassociated with a fetal anomaly, those women have a high incidence of pregnancy complications. Such patients were compared to a population with normal MS-AFP values to determine the incidence of historical risk factors and to ascertain if their presence affected the rate of pregnancy complications. A total of 358 patients were followed prospectively, 23 with elevated MS-AFP levels and 335 with normal levels (control group). Historical risk factors were more frequent in the patients with elevated MS-AFP levels. There was a fourfold increase in the rate of pregnancy complications when a patient had both risk factors and elevated MS-AFP levels as compared with elevated MS-AFP levels alone. In the control group, patients with known risk factors experienced twice the incidence of pregnancy complications as did patients with no risk factors. Using multiple logistic regression analysis, elevated MS-AFP levels were shown to be an independent variable in the risk assessment. The results of this study have wide application in the counseling and follow-up of patients identified by MS-AFP screening programs. |
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Authors:
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E L Capeless; P C Kelleher; C P Walters |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 37 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-05-21 Completed Date: 1992-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 257-60 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Medical Center Hospital of Vermont, Burlington 05401. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Hospitals, University Humans Incidence Logistic Models Mass Screening / methods, standards Medical History Taking Pregnancy Pregnancy Complications / blood, epidemiology*, prevention & control Prospective Studies Risk Factors Sensitivity and Specificity Vermont / epidemiology alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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