Document Detail

Elevated maternal serum AFP and normal ultrasound: what next?
MedLine Citation:
PMID:  7683199     Owner:  NLM     Status:  MEDLINE    
Given the discovery of intracranial changes observed in fetuses with open spina bifida, the wisdom of routinely performing amniocentesis on persons with unexplained maternal serum alpha-fetoprotein elevations is now being questioned. The detection rate for spina bifida with a targeted ultrasound examination is greater than 95%. Yet one must also consider the sensitivity of ultrasound in detecting other anomalies, such as ventral wall defects and fetal karyotype anomalies. Although the sensitivity of ultrasound for neural tube defects has improved dramatically in recent years, it cannot detect all chromosome or structural anomalies that may be detected by amniocentesis. Therefore, patients should be made aware of their specific risks following a targeted ultrasound and offered the option of amniocentesis.
C E Miller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in ultrasound, CT, and MR     Volume:  14     ISSN:  0887-2171     ISO Abbreviation:  Semin. Ultrasound CT MR     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-06-02     Completed Date:  1993-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8504689     Medline TA:  Semin Ultrasound CT MR     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-9     Citation Subset:  IM    
Intermountain Health Care, Department of Perinatology, Salt Lake City, UT 84143.
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MeSH Terms
Fetal Diseases / ultrasonography
Sensitivity and Specificity
Spina Bifida Cystica / diagnosis*,  genetics,  ultrasonography
Ultrasonography, Prenatal*
alpha-Fetoproteins / analysis*
Reg. No./Substance:

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