Document Detail

Elevated maternal plasma corticotropin-releasing hormone levels in pregnancies complicated by preterm labor.
MedLine Citation:
PMID:  1566770     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We investigated whether maternal plasma levels of the placental hormone corticotropin-releasing hormone are elevated in pregnancies complicated by preterm labor. STUDY DESIGN: Mean maternal corticotropin-releasing hormone levels were studied in women who met specific criteria for preterm labor and in women with normal pregnancies. Levels were also compared in the latent and active phases during term labor. RESULTS: In pregnancies complicated by preterm labor, maternal corticotropin-releasing hormone levels were higher than in normal pregnancies; this elevation occurred before labor was diagnosed clinically (p less than 0.05). When preterm labor was associated with infection, the mean levels were not elevated. Mean plasma levels were similar in latent and active phases during labor at term. CONCLUSION: Maternal plasma corticotropin-releasing hormone levels are elevated in association with preterm labor. This elevation does not appear to be due to labor itself and may reflect an early activation of the placenta before the onset of preterm labor.
W B Warren; S L Patrick; R S Goland
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  166     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-05-20     Completed Date:  1992-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1198-204; discussion 1204-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons, New York, NY 10032.
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MeSH Terms
Corticotropin-Releasing Hormone / blood*
Obstetric Labor, Premature / blood*,  complications,  drug therapy
Pregnancy / blood*
Pregnancy Complications, Infectious
Prospective Studies
Risk Factors
Tocolytic Agents / pharmacology
Uterine Contraction / drug effects
Grant Support
Reg. No./Substance:
0/Tocolytic Agents; 9015-71-8/Corticotropin-Releasing Hormone

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