| Elevated levels of tumor necrosis factor alpha in postdialysis fatigue. | |
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MedLine Citation:
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PMID: 9569129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postdialysis fatigue (PDF) has been ascribed to excessive ultrafiltration and decline in osmolality during hemodialysis. We evaluated the potential role for the sommogenic cytokines, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha), in the genesis of PDF Patients dialyzing with cuprophane membrane were assigned to PDF (N=25) and non-PDF (N=25) groups based on a fatigue index questionnaire. Pre- and postdialysis samples were obtained from 3 consecutive treatments and later assayed for serum levels of IL-1beta and TNFalpha by ELISA. Our results show significant intradialytic elevation of TNFalpha in both non-PDF groups (non-PDF: pre- 3.36+/-0.80 pg/ml to post 3.75+/-0.88 pg/ml, p<0.04; PDF: pre- 5.95+/-0.80 pg/ml to post- 8.66-/+1.35 pg/ml, p<0.02). The degree of intradialytic augmentation was significantly greater for TNFalpha in the PDF group (46+/-18% vs 11+/-5%; p<0.03). There were no significant intradialytic changes in serum levels of IL-1beta in either the PDF or non-PDF groups. There also were no significant differences in dialysis-related body weights, systolic blood pressures, or osmolalities. These findings suggest that TNFalpha may be involved in the pathogenesis of PDF. |
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Authors:
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A W Dreisbach; T Hendrickson; D Beezhold; L A Riesenberg; A H Sklar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The International journal of artificial organs Volume: 21 ISSN: 0391-3988 ISO Abbreviation: Int J Artif Organs Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-06-16 Completed Date: 1998-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802649 Medline TA: Int J Artif Organs Country: ITALY |
Other Details:
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Languages: eng Pagination: 83-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, United Health Services Hospitals, Binghamton, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biocompatible Materials Blood Pressure Body Weight Cellulose / analogs & derivatives Fatigue / blood, etiology* Female Humans Interleukin-1 / blood* Male Membranes, Artificial* Middle Aged Osmolar Concentration Outpatients Questionnaires Renal Dialysis / adverse effects* Tumor Necrosis Factor-alpha / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Interleukin-1; 0/Membranes, Artificial; 0/Tumor Necrosis Factor-alpha; 9004-34-6/Cellulose; 9050-09-3/cuprammonium cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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