Document Detail

Elevated levels of tumor necrosis factor alpha in postdialysis fatigue.
MedLine Citation:
PMID:  9569129     Owner:  NLM     Status:  MEDLINE    
Postdialysis fatigue (PDF) has been ascribed to excessive ultrafiltration and decline in osmolality during hemodialysis. We evaluated the potential role for the sommogenic cytokines, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha), in the genesis of PDF Patients dialyzing with cuprophane membrane were assigned to PDF (N=25) and non-PDF (N=25) groups based on a fatigue index questionnaire. Pre- and postdialysis samples were obtained from 3 consecutive treatments and later assayed for serum levels of IL-1beta and TNFalpha by ELISA. Our results show significant intradialytic elevation of TNFalpha in both non-PDF groups (non-PDF: pre- 3.36+/-0.80 pg/ml to post 3.75+/-0.88 pg/ml, p<0.04; PDF: pre- 5.95+/-0.80 pg/ml to post- 8.66-/+1.35 pg/ml, p<0.02). The degree of intradialytic augmentation was significantly greater for TNFalpha in the PDF group (46+/-18% vs 11+/-5%; p<0.03). There were no significant intradialytic changes in serum levels of IL-1beta in either the PDF or non-PDF groups. There also were no significant differences in dialysis-related body weights, systolic blood pressures, or osmolalities. These findings suggest that TNFalpha may be involved in the pathogenesis of PDF.
A W Dreisbach; T Hendrickson; D Beezhold; L A Riesenberg; A H Sklar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  21     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-16     Completed Date:  1998-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
Department of Medicine, United Health Services Hospitals, Binghamton, New York, USA.
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MeSH Terms
Biocompatible Materials
Blood Pressure
Body Weight
Cellulose / analogs & derivatives
Fatigue / blood,  etiology*
Interleukin-1 / blood*
Membranes, Artificial*
Middle Aged
Osmolar Concentration
Renal Dialysis / adverse effects*
Tumor Necrosis Factor-alpha / analysis*
Reg. No./Substance:
0/Biocompatible Materials; 0/Interleukin-1; 0/Membranes, Artificial; 0/Tumor Necrosis Factor-alpha; 9004-34-6/Cellulose; 9050-09-3/cuprammonium cellulose

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