| Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. | |
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MedLine Citation:
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PMID: 9147407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Creutzfeldt-Jakob disease (CJD) is a rare, fatal, neurodegenerative disease caused by a transmissible agent designated as proteinaceous infectious agent (prion). Searching for biochemical markers of CJD, we analysed cerebrospinal fluid (CSF) samples of 53 patients for tau-protein using an enzyme linked immunoassay (ELISA). In a group of 21 patients with definite CJD seen in the German case control study for CJD, tau-protein concentrations in CSF were significantly higher than in two control-groups of patients with other diseases (median 13,153 pg/ml, range 1,533-27,648 pg/ml; P = 0.0001). One group comprised 19 patients who were seen in the same study and were diagnosed as having other dementing diseases (tau concentration: median 558 pg/ml, range 233-1,769 pg/ml). The second control group comprised 13 patients from our hospital with no dementing disease (tau concentration: median 296 pg/ml, range 109-640 pg/ml). We conclude that determination of tau protein levels in CSF is a useful marker for laboratory diagnosis of CJD. |
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Authors:
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M Otto; J Wiltfang; H Tumani; I Zerr; M Lantsch; J Kornhuber; T Weber; H A Kretzschmar; S Poser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 225 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-07-18 Completed Date: 1997-07-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 210-2 Citation Subset: IM |
Affiliation:
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Department of Neurology, Georg-August-University Goettingen, Germany. 100634.133@compuserve.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Creutzfeldt-Jakob Syndrome / metabolism* Female Humans Male Middle Aged tau Proteins / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
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0/tau Proteins |
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