Document Detail


Elevated levels of soluble intercellular adhesion molecule-1 in the coronary circulation of patients with coronary organic stenosis and spasm.
MedLine Citation:
PMID:  10732847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cell surface expression of intercellular adhesion molecule-1 (ICAM-1) is upregulated following activation during inflammatory responses, mediating both cell migration and activation. The involvement of inflammation in unstable angina is suggested by the presence of activated circulating leukocytes. To examine whether plasma soluble ICAM-1 (sICAM-1) levels increase in the coronary circulation of patients with coronary organic stenosis and coronary spasm, plasma sICAM-1 levels were measured in the coronary sinus (CS) and the aortic root (Ao) simultaneously in 10 patients with 90% or more coronary narrowing and coronary spasm (coronary spastic angina (CSA) with organic stenosis), in 11 patients with coronary spasm and no significant coronary narrowing (CSA without organic stenosis), in 16 patients with stable exertional angina, and in 13 control subjects. The plasma sICAM-1 levels (ng/ml) in the CS increased in CSA with organic stenosis (230+/-26) as compared with CSA without organic stenosis (158+/-14), stable exertional angina (130+/-9) and control subjects (121+/-10) (p<0.01). The levels in the Ao also increased in CSA with organic stenosis (208+/-24) as compared with CSA without organic stenosis (149+/-13), stable exertional angina (130+/-11) and control subjects (121+/-10) (p<0.01). Furthermore, the plasma sICAM-1 levels were higher in the CS than in the Ao only in CSA with organic stenosis. These results suggest that activation of leukocytes occurs through the induction of ICAM-1 in the coronary circulation in the patients with CSA with organic stenosis.
Authors:
H Ogawa; T Sakamoto; K Nishiyama; H Soejima; K Kaikita; K Takazoe; S Miyamoto; K Kugiyama; M Yoshimura; H Yasue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese circulation journal     Volume:  64     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-16     Completed Date:  2000-05-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  170-6     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan. ogawah@kumamoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Circulation
Coronary Disease / blood*
Coronary Vasospasm / blood*
Female
Humans
Intercellular Adhesion Molecule-1 / blood*
Male
Middle Aged
Chemical
Reg. No./Substance:
126547-89-5/Intercellular Adhesion Molecule-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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