Document Detail

Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip.
MedLine Citation:
PMID:  15625614     Owner:  NLM     Status:  MEDLINE    
We compared type I collagen degradation using serum cross-linking C-terminal telopeptide (ICTP) in 18 patients with rapidly destructive osteoarthrosis and in 20 patients with slowly progressive osteoarthrosis of the hip. The diagnosis was established by clinical examination and radiographic evaluation. Total hip arthroplasty was performed in all patients. Serum levels of ICTP, bone-specific alkaline phosphatase, osteocalcin and N-terminal propeptide were studied. Patients with rapidly destructive osteoarthrosis had higher mean (SD) serum ICTP levels than patients with slowly progressive osteoarthrosis [13.2 (5.6) versus 3.7 ng/ml (1.4), p=0.001] whereas no significant difference of all other markers was seen between the groups. Elevation of ICTP levels correlated significantly with decreased joint-space width assessed by radiographs of the hip (p=0.01). Our data suggest that rapidly destructive hip osteoarthrosis is associated with elevated serum ICTP levels, reflecting increased collagen type I degradation.
Christian E Berger; Andreas Kröner; Helmar Stiegler; Thomas Leitha; Alfred Engel
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Publication Detail:
Type:  Journal Article     Date:  2004-12-30
Journal Detail:
Title:  International orthopaedics     Volume:  29     ISSN:  0341-2695     ISO Abbreviation:  Int Orthop     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-03     Completed Date:  2005-07-21     Revised Date:  2013-03-26    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Department of Orthopaedics, Danube Hospital, Langobardenstr. 122, 1220 Vienna, Austria.
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MeSH Terms
Aged, 80 and over
Arthroplasty, Replacement, Hip
Collagen / blood*
Collagen Type I / blood*
Disease Progression
Linear Models
Middle Aged
Osteoarthritis, Hip / blood*,  pathology,  surgery
Peptides / blood*
Reg. No./Substance:
0/Collagen Type I; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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