Document Detail

Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome.
MedLine Citation:
PMID:  16887214     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate whether patients with acute coronary syndrome (ACS) possessed high levels of platelet-monocyte aggregates (PMAs) and related circulating biomarkers. METHODS: 74 ACS patients, 58 stable angina pectoris (SAP) patients and 46 control patients without coronary artery disease were selected and their PMAs were measured by flow cytometry. Their plasma IL-6, IL-8, MCP-1, soluble CD40L and soluble P-selectin were also measured simultaneously by flow cytometry. RESULTS: Patients with ACS exhibited higher level of PMAs compared with SAP patients and the control. Furthermore, the levels of IL-6, IL-8, MCP-1, soluble CD40L, soluble P-selectin and CRP were also significantly higher in ACS patients than in SAP patients and the control group. However, there were no significant difference in the levels of IL-8, sCD40L, sP-selectin and CRP between SAP patients and the control group. Correlation analysis showed that high levels of IL-6 and sP-selectin were significantly correlated with PMAs. Logistic analysis further demonstrated that the presence of elevated CRP, IL-6 and PMAs level each confers an increased risk of ACS. CONCLUSION: Elevated levels of PMAs and related circulating biomarkers might indicate the unstable coronary syndrome in ACS patients, and the levels of PMAs, CRP and IL-6 could be used for monitoring and guiding the early intervention of ACS patients.
Junhong Wang; Songzhao Zhang; Yaping Jin; Guangming Qin; Lu Yu; Jinan Zhang
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Publication Detail:
Type:  Journal Article     Date:  2006-08-01
Journal Detail:
Title:  International journal of cardiology     Volume:  115     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  361-5     Citation Subset:  IM    
Cardiovascular Research Center, Division of Medicine, the first affiliated Hospital of Nanjing Medical University, Nanjing, 210029, PRC.
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MeSH Terms
Analysis of Variance
Biological Markers / blood
C-Reactive Protein / metabolism*
CD40 Ligand / blood
Coronary Angiography
Cross-Sectional Studies
Interleukin-6 / blood
Interleukin-8 / blood
Logistic Models
Middle Aged
Myocardial Infarction / blood*,  physiopathology*,  radiography
P-Selectin / blood*
Platelet Activating Factor / metabolism*
Reference Values
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Statistics, Nonparametric
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 0/Interleukin-8; 0/P-Selectin; 0/Platelet Activating Factor; 147205-72-9/CD40 Ligand; 9007-41-4/C-Reactive Protein

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