Document Detail

Elevated levels of plasma prekallikrein, high molecular weight kininogen and factor XI in coronary heart disease.
MedLine Citation:
PMID:  11888508     Owner:  NLM     Status:  MEDLINE    
Increased levels of hemostatic factors may play a role in the pathogenesis of myocardial infarction by triggering thrombin formation. We measured factor XII (FXII), factor XI (FXI), plasma prekallikrein (PK) and high-molecular-weight kininogen (HK) in 200 patients having survived myocardial infarction for at least 2 months, and in 100 healthy controls. We found significantly elevated levels of FXI clotting activity (FXI:C), HK:C and of the amidolytic activity of PK (PK:Am) among the patients as compared to the controls. Plasma levels of FXI:C, HK:C and PK:Am in the highest quartile were associated with an odds ratio of 1.9 (95% CI: 1.0-3.8), 2.0 (95% CI: 1.0-4.0) and 5.4 (95% CI: 2.6-11.2), respectively, compared to the respective plasma levels in the lowest quartile. After correction for established clinical and laboratory risk factors, the association between PK:Am plasma levels and myocardial infarction remained significant (P=0.0007). Combination of high PK:Am plasma levels and smoking or arterial hypertension, respectively, resulted in a more than additive relative risk for myocardial infarction.
Christoph Merlo; Walter A Wuillemin; Maurice Redondo; Miha Furlan; Irmela Sulzer; Johanna Kremer-Hovinga; Bernd R Binder; Bernhard Lämmle
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  161     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-12     Completed Date:  2002-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  261-7     Citation Subset:  IM    
Central Hematology Laboratory, University of Bern, Inselspital, CH-3010 Bern, Switzerland.
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MeSH Terms
Biological Markers / analysis
Case-Control Studies
Cohort Studies
Confidence Intervals
Factor XI / analysis,  metabolism*
Kininogen, High-Molecular-Weight / analysis,  blood*
Middle Aged
Myocardial Infarction / blood*,  physiopathology*
Odds Ratio
Prekallikrein / analysis,  metabolism*
Reference Values
Risk Assessment
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 0/Kininogen, High-Molecular-Weight; 9013-55-2/Factor XI; 9055-02-1/Prekallikrein

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