| Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. | |
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MedLine Citation:
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PMID: 11306523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is accumulating data that acute coronary syndromes relate to recent onset activation of inflammation affecting atherosclerotic plaques. Increased blood levels of oxidized low density lipoprotein (ox-LDL) could play a role in these circumstances. METHODS AND RESULTS: Ox-LDL levels were measured in 135 patients with acute myocardial infarction (AMI; n=45), unstable angina pectoris (UAP; n=45), and stable angina pectoris (SAP; n=45) and in 46 control subjects using a sandwich ELISA method. In addition, 33 atherectomy specimens obtained from a different cohort of patients with SAP (n=10) and UAP (n=23) were studied immunohistochemically for ox-LDL. In AMI patients, ox-LDL levels were significantly higher than in patients with UAP (P<0.0005) or SAP (P<0.0001) or in controls (P<0.0001) (AMI, 1.95+/-1.42 ng/5 microgram LDL protein; UAP, 1.19+/-0.74 ng/5 microgram LDL protein; SAP, 0.89+/-0.48 ng/5 microgram LDL protein; control, 0.58+/-0.23 ng/5 microgram LDL protein). Serum levels of total, HDL, and LDL cholesterol did not differ among these patient groups. In the atherectomy specimens, the surface area containing ox-LDL-positive macrophages was significantly higher in patients with UAP than in those with SAP (P<0.0001). CONCLUSIONS: This study demonstrates that ox-LDL levels show a significant positive correlation with the severity of acute coronary syndromes and that the more severe lesions also contain a significantly higher percentage of ox-LDL-positive macrophages. These observations suggest that increased levels of ox-LDL relate to plaque instability in human coronary atherosclerotic lesions. |
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Authors:
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S Ehara; M Ueda; T Naruko; K Haze; A Itoh; M Otsuka; R Komatsu; T Matsuo; H Itabe; T Takano; Y Tsukamoto; M Yoshiyama; K Takeuchi; J Yoshikawa; A E Becker |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Circulation Volume: 103 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-18 Completed Date: 2001-05-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 1955-60 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Osaka City General Hospital, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris
/
blood*,
diagnosis,
surgery Angina, Unstable / blood*, diagnosis, surgery Atherectomy, Coronary Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Cohort Studies Coronary Artery Disease / metabolism*, pathology, surgery Enzyme-Linked Immunosorbent Assay / methods Female Humans Immunohistochemistry Lipoproteins, LDL / metabolism* Macrophages / metabolism, pathology Male Middle Aged Myocardial Infarction / blood*, diagnosis Predictive Value of Tests Risk Factors Sensitivity and Specificity Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 57-88-5/Cholesterol |
| Comments/Corrections | |
Comment In:
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Circulation. 2001 Apr 17;103(15):1930-2
[PMID:
11306518
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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