Document Detail

Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes.
MedLine Citation:
PMID:  11306523     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is accumulating data that acute coronary syndromes relate to recent onset activation of inflammation affecting atherosclerotic plaques. Increased blood levels of oxidized low density lipoprotein (ox-LDL) could play a role in these circumstances. METHODS AND RESULTS: Ox-LDL levels were measured in 135 patients with acute myocardial infarction (AMI; n=45), unstable angina pectoris (UAP; n=45), and stable angina pectoris (SAP; n=45) and in 46 control subjects using a sandwich ELISA method. In addition, 33 atherectomy specimens obtained from a different cohort of patients with SAP (n=10) and UAP (n=23) were studied immunohistochemically for ox-LDL. In AMI patients, ox-LDL levels were significantly higher than in patients with UAP (P<0.0005) or SAP (P<0.0001) or in controls (P<0.0001) (AMI, 1.95+/-1.42 ng/5 microgram LDL protein; UAP, 1.19+/-0.74 ng/5 microgram LDL protein; SAP, 0.89+/-0.48 ng/5 microgram LDL protein; control, 0.58+/-0.23 ng/5 microgram LDL protein). Serum levels of total, HDL, and LDL cholesterol did not differ among these patient groups. In the atherectomy specimens, the surface area containing ox-LDL-positive macrophages was significantly higher in patients with UAP than in those with SAP (P<0.0001). CONCLUSIONS: This study demonstrates that ox-LDL levels show a significant positive correlation with the severity of acute coronary syndromes and that the more severe lesions also contain a significantly higher percentage of ox-LDL-positive macrophages. These observations suggest that increased levels of ox-LDL relate to plaque instability in human coronary atherosclerotic lesions.
S Ehara; M Ueda; T Naruko; K Haze; A Itoh; M Otsuka; R Komatsu; T Matsuo; H Itabe; T Takano; Y Tsukamoto; M Yoshiyama; K Takeuchi; J Yoshikawa; A E Becker
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Circulation     Volume:  103     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-18     Completed Date:  2001-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1955-60     Citation Subset:  IM    
Department of Cardiology, Osaka City General Hospital, Osaka, Japan.
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MeSH Terms
Angina Pectoris / blood*,  diagnosis,  surgery
Angina, Unstable / blood*,  diagnosis,  surgery
Atherectomy, Coronary
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Cohort Studies
Coronary Artery Disease / metabolism*,  pathology,  surgery
Enzyme-Linked Immunosorbent Assay / methods
Lipoproteins, LDL / metabolism*
Macrophages / metabolism,  pathology
Middle Aged
Myocardial Infarction / blood*,  diagnosis
Predictive Value of Tests
Risk Factors
Sensitivity and Specificity
Severity of Illness Index
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 57-88-5/Cholesterol
Comment In:
Circulation. 2001 Apr 17;103(15):1930-2   [PMID:  11306518 ]

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