Document Detail

Elevated levels of human salivary epidermal growth factor after oral and juxtaoral surgery.
MedLine Citation:
PMID:  9973123     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Saliva provides a natural reservoir of growth factors whose purposes have remained elusive. Animal studies suggest that saliva-derived growth factors play a role in systemic and oral wound healing. In the current study, salivary concentrations of epidermal growth factor (EGF) were monitored in patients before and after oral and juxtaoral surgery. PATIENTS AND METHODS: Whole resting saliva was collected from a group of patients with parotid gland tumors requiring surgical resection. Another group of patients a history of periodontal disease requiring surgical intervention also provided whole salivary samples. Healthy age- and sex-matched persons served as controls. RESULTS: Salivary EGF levels were elevated in both groups of patients within 24 hours after surgery. In the periodontitis patients, a second smaller peak was assayed noted between 36 and 48 hours. After this, EGF concentrations returned to levels comparable to healthy controls in both experimental groups. CONCLUSIONS: Although the local cells have the ability to synthesize and secrete growth factors at a site of injury, these results suggest that surgery stimulates increased synthesis and secretion of growth factors in the saliva as well. This increased level of saliva-derived growth factor may also aid in promoting wound healing.
G E Oxford; R Jonsson; J Olofsson; T Zelles; M G Humphreys-Beher
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  57     ISSN:  0278-2391     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-24     Completed Date:  1999-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  154-8; discussion 158-9     Citation Subset:  AIM; D; IM    
Department of Periodontology, University of Florida, Gainesville 32610-0434, USA.
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MeSH Terms
Analysis of Variance
Case-Control Studies
Epidermal Growth Factor / analysis*,  biosynthesis,  secretion
Follow-Up Studies
Linear Models
Logistic Models
Middle Aged
Parotid Neoplasms / surgery*
Periodontitis / surgery*
Saliva / chemistry*,  metabolism,  secretion
Wound Healing
Grant Support
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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