| Elevated levels of human endogenous retrovirus-W transcripts in blood cells from patients with first episode schizophrenia. | |
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MedLine Citation:
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PMID: 17559415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported on the differential presence of transcripts related to the human endogenous retrovirus (HERV)-W family in cerebrospinal fluid and plasma from patients with first-episode schizophrenia compared with control individuals. Whether this is a consequence of qualitative or quantitative differences in transcription of genomic regions harboring HERV-W elements is not known. The purpose of the present study was therefore to characterize the transcribed HERV-W elements in mononuclear cells obtained from 30 patients first hospitalized for schizophrenia-related psychosis and from 26 healthy control individuals. We observed elevated total levels of HERV-W gag (2.1-fold, P < 0.01) but not env transcripts in the cells of patients compared with controls. By using the melting temperatures of the amplicons as a proxy marker for sequence identity, no absolute qualitative differences was detected between the two groups. Mapping of the detected transcripts identified several intronic and intergenic HERV-W elements transcribed in the cells, including elements previously considered transcriptionally silent. Element-specific assays revealed elevated levels of intronic transcripts containing HERV-W gag sequence from the putative gene PTD015 on chromosome 11q13.5 (1.6-fold, P < 0.05) in the patients compared with the controls. Thus, studies aiming to further understanding of complex human disease such as schizophrenia may need to be extended beyond the strictly protein-coding fraction of the transcriptome. |
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Authors:
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Y Yao; J Schröder; C Nellåker; C Bottmer; S Bachmann; R H Yolken; H Karlsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-07 |
Journal Detail:
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Title: Genes, brain, and behavior Volume: 7 ISSN: 1601-183X ISO Abbreviation: Genes Brain Behav. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-21 Completed Date: 2008-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101129617 Medline TA: Genes Brain Behav Country: England |
Other Details:
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Languages: eng Pagination: 103-12 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosomes, Human, Pair 11 Endogenous Retroviruses / genetics* Gene Expression Profiling Gene Expression Regulation, Viral / physiology Gene Products, gag / genetics Humans Introns / genetics Lymphocytes / virology Psychotic Disorders / genetics, virology* Reverse Transcriptase Polymerase Chain Reaction Schizophrenia / genetics, virology* Sequence Analysis, DNA Transcription, Genetic / genetics* Viral Envelope Proteins / genetics |
| Chemical | |
Reg. No./Substance:
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0/Gene Products, gag; 0/Viral Envelope Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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