Document Detail

Elevated levels of high-sensitivity C-reactive protein and serum amyloid-A late after Kawasaki disease: association between inflammation and late coronary sequelae in Kawasaki disease.
MedLine Citation:
PMID:  15611368     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Coronary sequelae that persist after Kawasaki disease (KD) have been associated with obstructive changes of the lesions and coronary vascular events in adolescents and young adults. However, little is known about the association between sequelae late after KD and inflammatory markers, which are potential mediators and markers for atherogenesis. METHODS AND RESULTS: Cross-sectional study was performed to test the hypothesis that coronary sequelae are associated with elevated levels of inflammatory markers in patients late after KD (mean time interval after the onset, 10 years, 10 months). Levels of high-sensitivity C-reactive protein (CRP), serum amyloid-A (SAA), interleukin-6, and soluble intercellular adhesion molecule-1 were measured in the 4 groups (n=80): the referent group (n=15) and KD subgroups with normal coronary arteries from the onset (n=27); with regressed aneurysms (n=18); and with coronary artery lesions, such as persistent aneurysms, stenosis, and occlusion (n=20). CRP levels were significantly elevated in a KD subgroup with coronary artery lesions compared with the referent or other KD subgroups, as analyzed by ANOVA and ANCOVA after adjustment for a confounding factor body mass index. Levels of CRP, SAA, and interleukin-6 were positively correlated. Stepwise regression and logistic regression analyses support the association between the persistence of coronary artery lesions and the levels of CRP and SAA. CONCLUSIONS: Results demonstrate that the persistence of coronary lesions late after KD was independently associated with levels of CRP and SAA, suggesting that inflammation may be a novel functional aspect of coronary artery diseases late after KD.
Yoshihide Mitani; Hirofumi Sawada; Hidetoshi Hayakawa; Kenzo Aoki; Hiroyuki Ohashi; Masahiko Matsumura; Kenji Kuroe; Hideto Shimpo; Masataka Nakano; Yoshihiro Komada
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2004-12-20
Journal Detail:
Title:  Circulation     Volume:  111     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-04     Completed Date:  2005-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-43     Citation Subset:  AIM; IM    
Department of Pediatrics, Mie University School of Medicine, 2-174 Edobashi, Tsu City, Mie Prefecture, 514-8507, Japan.
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MeSH Terms
Biological Markers
C-Reactive Protein / analysis*
Coronary Aneurysm / blood,  etiology
Coronary Angiography
Coronary Artery Disease / etiology
Coronary Disease / blood,  etiology*
Coronary Stenosis / blood,  etiology
Cross-Sectional Studies
Disease Susceptibility
Inflammation / blood
Intercellular Adhesion Molecule-1 / blood
Interleukin-6 / blood
Mucocutaneous Lymph Node Syndrome / blood*,  complications,  pathology
Serum Amyloid A Protein / analysis*
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 0/Serum Amyloid A Protein; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-41-4/C-Reactive Protein

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