Document Detail


Elevated levels of antibodies against 70 kDa heat shock proteins in the sera of patients with HIV infection.
MedLine Citation:
PMID:  14556258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heat shock proteins (Hsp), especially 70 kDa heat shock protein (Hsp70) play an important role in the life cycle of HIV-1 virus. Hsp70 is overexpressed in HIV-infected cells and this is the most abundant Hsp associated with HIV virions. The aim of our study was to investigate whether HIV infection increases the extent of specific humoral immune response against Hsp70. The serum concentration of anti-Hsp70 IgG antibodies was measured in 47 HIV-infected patients, and 62 healthy, HIV-seronegative persons. Nineteen patients on highly active anti-retroviral therapy (HAART) were followed for 24 months in a longitudinal study. Anti-Hsp70 antibodies were measured by ELISA, using recombinant human Hsp70. Levels of anti-Hsp70 antibodies were significantly (P < 0.0001) higher in the HIV-infected patients (median: 1409 (25th-75th percentile: 1031-2214) AU/ml) than in healthy control subjects (626 (429-970) AU/ml). In 19 HIV patients, serum levels of anti-Hsp70 antibodies significantly (P < 0.001) decreased during 24 (11-41) months HAART (1309 (887-2213) AU/ml before and 640 (386-959) AU/ml during HAART), accompanied by viral load reduction and CD4+ count elevation. It is concluded that HIV-infection induces a marked increase in the anti-Hsp70 antibody levels, which is consistent with the enhanced expression of Hsp70 on the surface of HIV-infected cells and/or incorporation of the protein into the membrane of HIV virions.
Authors:
Judit Kocsis; Zoltán Prohászka; Adrienn Bíró; George Füst; Dénes Bánhegyi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  71     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-10-13     Completed Date:  2004-01-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  480-2     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Affiliation:
3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Case-Control Studies
Female
HIV Infections / drug therapy,  immunology*,  virology
HSP70 Heat-Shock Proteins / immunology*
Humans
Immunoglobulin G / blood*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/HSP70 Heat-Shock Proteins; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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