Document Detail

Elevated left ventricular filling pressure after maximal exercise predicts increased plasma B-type natriuretic peptide levels in patients with impaired relaxation pattern of diastolic filling.
MedLine Citation:
PMID:  17617309     Owner:  NLM     Status:  MEDLINE    
Patients with an impaired relaxation pattern of Doppler left ventricular filling may have elevated or normal plasma B-type natriuretic peptide (BNP) levels. We hypothesized that elevated BNP levels occur in patients whose left atrial pressure increases after exercise. We examined the relationship between BNP levels and left ventricular filling pressure at rest and immediately after maximal exercise, estimated by Doppler tissue imaging, in 80 patients undergoing exercise echocardiography and showing impaired relaxation pattern. The ratio of early diastolic mitral inflow to annular velocities at rest did not correlate with BNP (r = 0.13, P = .23). In contrast, ratio of early diastolic mitral inflow to annular velocities after exercise correlated with BNP (r = 0.57, P < .001). Ratio of early diastolic mitral inflow to annular velocities after exercise greater than 9.9 discriminated patients with BNP greater than 100 pg/mL (n = 16) from those with BNP less than 100 pg/mL (n = 64) with a sensitivity of 75% and a specificity of 84%. In conclusion, elevated left ventricular filling pressure after maximal exercise predicts increased BNP levels in patients with impaired relaxation pattern.
Hidekatsu Fukuta; William C Little
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  20     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-08-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  832-7     Citation Subset:  IM    
Cardiology Section, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1045, USA.
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MeSH Terms
Blood Pressure Determination
Exercise Test*
Hypertension / blood*,  ultrasonography*
Hypertrophy, Left Ventricular / blood*,  ultrasonography*
Middle Aged
Natriuretic Peptide, Brain / blood*
Physical Endurance*
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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