| Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis. | |
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MedLine Citation:
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PMID: 20837855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals. DESIGN: Prospective case-control series. SETTING: Academic referral center. PATIENTS: Twenty-six controls with noninflammatory neurologic disease and 35 patients with MS donated serum and CSF for recombinant MOG (rMOG) antibody determination. MAIN OUTCOME MEASURES: Serum and CSF rMOG antibody and albumin levels were used to calculate an rMOG index. Clinical disability, CSF markers, and magnetic resonance metrics were correlated with the rMOG index. RESULTS: The rMOG index was elevated in MS patients compared with controls (P = .01). Patients with progressive MS exhibited elevated rMOG indexes compared with patients with relapsing-remitting MS (P = .04). The rMOG index was inferior to the IgG index in differentiating MS patients from controls. However, 7 of 16 patients with MS who had normal immunoglobulin G indexes had an elevated rMOG index. The rMOG index did not correlate with clinical disability, other CSF markers, or radiographic outcome measures. CONCLUSIONS: The rMOG index, a marker of intrathecal MOG antibody production, may provide complementary information to routine CSF testing in the diagnosis of MS. Furthermore, intrathecal anti-MOG antibody production may be more pronounced in progressive than in relapsing forms of MS. |
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Authors:
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Eric C Klawiter; Laura Piccio; Jeri-Anne Lyons; Robert Mikesell; Kevin C O'Connor; Anne H Cross |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of neurology Volume: 67 ISSN: 1538-3687 ISO Abbreviation: Arch. Neurol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-14 Completed Date: 2010-10-01 Revised Date: 2011-08-23 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1102-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Washington University, St Louis, MO 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Multiple Sclerosis / blood, cerebrospinal fluid*, immunology* Myelin-Associated Glycoprotein / blood, cerebrospinal fluid*, immunology* Prospective Studies Severity of Illness Index Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
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CO6 RR020092/CO/NCI NIH HHS; K24 RR017100-01A2/RR/NCRR NIH HHS; UL1 RR024992-02/RR/NCRR NIH HHS; UL1RR024992/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Myelin-Associated Glycoprotein; 0/myelin oligodendrocyte glycoprotein |
| Comments/Corrections | |
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