Document Detail


Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.
MedLine Citation:
PMID:  20837855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals.
DESIGN: Prospective case-control series.
SETTING: Academic referral center.
PATIENTS: Twenty-six controls with noninflammatory neurologic disease and 35 patients with MS donated serum and CSF for recombinant MOG (rMOG) antibody determination.
MAIN OUTCOME MEASURES: Serum and CSF rMOG antibody and albumin levels were used to calculate an rMOG index. Clinical disability, CSF markers, and magnetic resonance metrics were correlated with the rMOG index.
RESULTS: The rMOG index was elevated in MS patients compared with controls (P = .01). Patients with progressive MS exhibited elevated rMOG indexes compared with patients with relapsing-remitting MS (P = .04). The rMOG index was inferior to the IgG index in differentiating MS patients from controls. However, 7 of 16 patients with MS who had normal immunoglobulin G indexes had an elevated rMOG index. The rMOG index did not correlate with clinical disability, other CSF markers, or radiographic outcome measures.
CONCLUSIONS: The rMOG index, a marker of intrathecal MOG antibody production, may provide complementary information to routine CSF testing in the diagnosis of MS. Furthermore, intrathecal anti-MOG antibody production may be more pronounced in progressive than in relapsing forms of MS.
Authors:
Eric C Klawiter; Laura Piccio; Jeri-Anne Lyons; Robert Mikesell; Kevin C O'Connor; Anne H Cross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of neurology     Volume:  67     ISSN:  1538-3687     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2010-10-01     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1102-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Multiple Sclerosis / blood,  cerebrospinal fluid*,  immunology*
Myelin Proteins
Myelin-Associated Glycoprotein / blood,  cerebrospinal fluid*,  immunology*
Myelin-Oligodendrocyte Glycoprotein
Prospective Studies
Severity of Illness Index
Statistics, Nonparametric
Grant Support
ID/Acronym/Agency:
CO6 RR020092/CO/NCI NIH HHS; K24 RR017100-01A2/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992-02/RR/NCRR NIH HHS; UL1RR024992/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/MOG protein, human; 0/Myelin Proteins; 0/Myelin-Associated Glycoprotein; 0/Myelin-Oligodendrocyte Glycoprotein
Comments/Corrections

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