Document Detail


Elevated intraesophageal pressure in patients with achalasia: a common and important manometric finding.
MedLine Citation:
PMID:  14714608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is a subgroup of patients with achalasia in which manometry shows elevated intraesophageal pressure, expressed by elevation of esophageal baseline relative to gastric pressure. The aim of this study was to determine the prevalence of elevated intraesophageal pressure in patients with achalasia and its relationship to clinical, radiographic, endoscopic, and other manometric findings. Manometric studies of 62 patients with achalasia were analyzed and elevated intraesophageal pressure was considered any positive elevation of esophageal baseline relative to gastric pressure. Multiple regression analysis was used to determine independent risk factors associated with elevated intraesophageal pressure. Elevated intraesophageal pressure was found in 32 patients (51.6%). Lower esophageal sphincter pressure was the only independent variable associated with elevated intraesophageal pressure (P = 0.0167). Mean lower esophageal sphincter pressure was significantly higher in patients with elevated compared to those with normal intraesophageal pressure (34 +/- 1.96 vs 26.5 +/- 1.73 mm Hg; P = 0.006). In addition, lower esophageal sphincter pressure had a positive correlation with intraesophageal pressure (r = 0.49, P < 0.001). Conversely, no correlation was found between elevated intraesophageal pressure and various symptoms, disease duration, radiologic dilation, a finding of retained fluid during endoscopy, and esophageal length. We conclude that elevated intraesophageal pressure is a common manometric finding in patients with achalasia, with a prevalence of 51.6%, and is associated with significantly higher lower esophageal sphincter pressure.
Authors:
Dimitrios K Kamberoglou; Evanthia P Zambeli; Panagiotis A Triantafyllopoulos; Nikolaos G Margetis; Nikolaos K Gavalakis; Vassilios D Tzias
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  48     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-12     Completed Date:  2004-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2242-6     Citation Subset:  AIM; IM    
Affiliation:
Endoscopy Department, First IKA Hospital, Athens, Greece. kamberd@hol.gr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Esophageal Achalasia / pathology,  physiopathology*,  radiography
Esophagogastric Junction / physiopathology*,  radiography
Esophagoscopy
Female
Humans
Male
Manometry
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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