Document Detail


Elevated interstitial fluid volume in soleus muscles unweighted by spaceflight or suspension.
MedLine Citation:
PMID:  8282616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent evidence by Kandarian et al. (J. Appl. Physiol. 71: 910-914, 1991) indicates that prolonged (28 days) unweighting of the rat soleus by hindlimb suspension results in a substantial increase in interstitial fluid volume (IFV), as defined by the inulin space. The lack of any significant difference in absolute IFV values between unweighted and control groups suggested that this elevated IFV was a consequence of muscle atrophy. Using young female rats, we directly tested this hypothesis by comparing the early responses of soleus muscle weight and IFV with unweighting by tail-cast suspension or actual exposure to microgravity during spaceflight. Significant differences from control were first observed after 3 days of suspension unweighting for soleus wet weight (-14%; P < 0.01) and IFV (+35%; P < 0.01) and increased further after 6 days (-32% and +53%, respectively; both P < 0.001). After 5.4 days of spaceflight, soleus wet weight was 38% less and IFV was 52% greater than control (both P < 0.001). A highly significant negative correlation between soleus wet weight and IFV for all groups was observed (r = -0.70, P < 0.001). These data indicate that elevated soleus IFV develops at an early time point during unweighting and that there is a direct relationship between the magnitude of this increase in IFV and the extent of muscle atrophy. This relationship also exists in soleus muscles unweighted by exposure to a microgravity environment.
Authors:
E J Henriksen; M E Tischler; C R Woodman; K A Munoz; C S Stump; C R Kirby
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  75     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-02-14     Completed Date:  1994-02-14     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1650-3     Citation Subset:  IM; S    
Affiliation:
Department of Exercise and Sport Sciences, University of Arizona, Tucson 85721.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrophy / pathology
Extracellular Space / physiology*
Female
Muscles / anatomy & histology,  physiology*
Organ Size / physiology
Rats
Rats, Sprague-Dawley
Space Flight*
Weightlessness / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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