| Elevated interleukin-8 in cervical mucus as an indicator for treatment to prevent premature birth and preterm, pre-labor rupture of membranes: a prospective study. | |
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MedLine Citation:
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PMID: 15209391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: We investigated whether cervical shortening and high interleukin (IL)-8 in cervical mucus were valuable indications for treatment to prevent premature birth and preterm, pre-labor rupture of membranes (pPROM). METHOD OF STUDY: Pregnant women were divided into group A, in which neither cervical IL-8 nor cervical length was measured in the middle trimester; and groups B and C, in which cervical length and cervical IL-8 were measured, and bed rest or cerclage was performed when cervical shortening was detected. In group B, vaginal washing with povidone iodine and insertion of chloramphenicol vaginal tablets were carried out in women with IL-8 elevations. RESULTS: In group B, duration of pregnancy was significantly prolonged compared with group A and C, and occurrence of pPROM was significantly lower. No significant differences were found in those rates between groups A and C. CONCLUSION: Successful treatment for women with IL-8 elevations in cervical mucus decreased rates of premature birth or pPROM. |
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Authors:
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Masatoshi Sakai; Yasushi Sasaki; Satoshi Yoneda; Tadashi Kasahara; Takashi Arai; Masatoshi Okada; Hitoshi Hosokawa; Kiyoshi Kato; Yoshikatsu Soeda; Shigeru Saito |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 51 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-06-22 Completed Date: 2004-10-19 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 220-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cervix Mucus
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drug effects,
metabolism* Chloramphenicol / pharmacology, therapeutic use Disease Susceptibility Female Fetal Membranes, Premature Rupture / diagnosis*, metabolism, prevention & control* Humans Interleukin-8 / metabolism* Obstetric Labor, Premature / diagnosis*, metabolism, prevention & control* Pregnancy Pregnancy Outcome Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-8; 56-75-7/Chloramphenicol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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