| Elevated inflammatory mediators and pulmonary hypertension after applying an extracorporeal circuit in a neonatal sepsis model. | |
| | |
MedLine Citation:
|
PMID: 20859634 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
PURPOSE: We aimed to study the changes in cytokines, oxidative mediators, and pulmonary blood pressure in a neonatal sepsis model when applying an extracorporeal circuit (ECC). METHODS: Of 28 anesthetized and mechanically ventilated 3-day-old piglets, 14 underwent cecal ligation and perforation (CLP), of which 7 underwent ECC for 3 h from 3 to 6 h after CLP. The remaining 14 were sham, of which 7 underwent ECC. Serum interleukin (IL)-6, IL-10, tumor necrosis factor (TNF), interferon gamma (IFN-γ), total hydroperoxide (TH), nitric oxide metabolites (NOx), and mean pulmonary arterial blood pressure (mPAP)/mean arterial blood pressure (mABP) ratio were measured at pre-CLP and at 3, 6, and 9 h in the CLP groups, and continued in the sham groups at 12, 15, 18, and 24 h. RESULTS: The CLP group with ECCs compared to the CLP group without it showed higher levels of serum IL-6, IL-10, and NOx at 6 h and higher levels of serum TH at 6 and 9 h. The sham group with ECCs compared to the one without it showed higher levels of serum IL-6 and IL-10 at 12, 15, and 18 h, TH at 6 and 9 h, TNF at 6 h, and IFN-γ at 9 h. The mPAP/mABP ratios in the CLP group with ECCs were higher compared to the CLP group without it at 6 and 9 h. CONCLUSION: Applying ECCs provoked a window of cytokines, free radicals elevation, and pulmonary hypertension which could be hazardous in critically ill newborns. |
| | |
Authors:
|
Mohamed Hamed Hussein; Ghada Abdel-Hamid Daoud; Takashi Hashimoto |
Related Documents
:
|
7750314 - Systemic to pulmonary bronchial blood flow in heart failure. 9202644 - Decreased myogenic reactivity in skeletal muscle arterioles after hypothermic cardiopul... 1356164 - The effects of phentolamine and nitroglycerin on right-sided hemodynamics in cardiac pa... 10875714 - Changes in gastric intramucosal ph and circulating blood volume following coronary arte... 9372484 - Effect of alterations in blood volume on cardiac function during maximal exercise. 15722654 - Combination therapy in the management of hypertension: focus on angiotensin receptor bl... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pediatric surgery international Volume: 27 ISSN: 1437-9813 ISO Abbreviation: Pediatr. Surg. Int. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8609169 Medline TA: Pediatr Surg Int Country: Germany |
Other Details:
|
Languages: eng Pagination: 53-60 Citation Subset: IM |
Affiliation:
|
Research Center, VACSERA, Giza, Egypt. hamed@med.nagoya-cu.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Single-incision pediatric endosurgery: lessons learned from our first 224 laparoendoscopic single-si...
Next Document: Analysis of snoring sound by psychoacoustic parameters.