Document Detail

Elevated high molecular weight fibrinogen in plasma is predictive of coronary ischemic events after acute myocardial infarction.
MedLine Citation:
PMID:  10595627     Owner:  NLM     Status:  MEDLINE    
This study investigates the association between the concentration and function of plasma fibrinogen molecules measured at the time of hospital admission in patients with acute myocardial infarction (AMI), with reference to the risk of new coronary ischemic events during a three-day follow-up period of. Before starting fibrinolytic and anticoagulant treatment plasma fibrinogen, high molecular weight fibrinogen (HMW-fibrinogen), fibrin formation rate (FbFR) and phosphorous content in fibrinogen were determined in 90 AMI patients. During a three-day follow-up period 12 patients suffered new ischemic events. The 12 patients with coronary ischemia had higher concentrations of plasma fibrinogen (312+/-23 vs. 270+/-73 mg/dl, p<0.05) and HMW-fibrinogen (246+/-35 vs. 189+/-23 mg/dl, p<0.001) and a higher FbFR (65+/-30 vs. 40+/-25, p<0.001) than patients without these events. No association was found between the phosphorous content in fibrinogen and new coronary ischemic events. We conclude that after myocardial infarction an elevated plasma level of HMW-fibrinogen and a high FbFR value at the time of hospital admission are associated with new coronary ischemic events during a three-day follow-up period.
E Reganon; V Vila; F Ferrando; V Martínez-Sales; L Fayos; M Ruano; J Aznar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  82     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-02-14     Completed Date:  2000-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1403-5     Citation Subset:  IM    
Research Center, La Fe University Hospital, Valencia, Spain.
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MeSH Terms
Biological Markers
Coronary Thrombosis / blood*,  epidemiology
Fibrin / analysis
Fibrinogen / analysis*,  chemistry
Fibrinopeptide A / analysis
Follow-Up Studies
Middle Aged
Molecular Weight
Myocardial Infarction / blood*,  epidemiology
Phosphorus / analysis
Protein Processing, Post-Translational
Reg. No./Substance:
0/Biological Markers; 25422-31-5/Fibrinopeptide A; 7723-14-0/Phosphorus; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen

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