Document Detail


Elevated granulocyte colony-stimulating factor levels predict treatment failure in patients with Kawasaki disease.
MedLine Citation:
PMID:  18930517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Kawasaki disease (KD) is an acute vasculitis in young children, frequently associated with coronary artery aneurysms. The intravenous infusion of high-dose IgG (IVIG) effectively reduces the systemic inflammation and the incidence of coronary artery lesions, although the precise underlying mechanisms are unknown. OBJECTIVE: We performed expression profiling of whole blood cells to investigate the mechanisms underlying the effect of IVIG and to identify biomarkers associated with unresponsiveness to IVIG. METHODS: We compared the transcript abundance among pre-IVIG and post-IVIG patients and febrile control patients. Then we analyzed the mRNA levels and the protein levels among the different cohort of patients with KD who were either responsive or nonresponsive to the initial IVIG. RESULTS: A total of 298 transcripts were overrepresented or underrepresented in the pre-IVIG patients compared with post-IVIG patients and febrile controls, of which 15 transcripts were differentially expressed in nonresponsive patients with KD compared with responsive patients before IVIG. The protein levels of polycythemia rubra vera 1, which was one of the most variably expressed transcripts in pre-IVIG patients, and the serum granulocyte colony-stimulating factor levels were significantly higher in nonresponsive patients than in responsive patients before the initial IVIG administration. CONCLUSION: These findings suggest that the variable gene expression profiles were correlated to the responses of patients with KD to IVIG administration. Polycythemia rubra vera 1 and granulocyte colony-stimulating factor levels may be good biomarkers for predicting response to IVIG in patients with KD.
Authors:
Jun Abe; Ryota Ebata; Toshiaki Jibiki; Kumi Yasukawa; Hirohisa Saito; Masaru Terai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-19
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  122     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2008-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1008-1013.e8     Citation Subset:  AIM; IM    
Affiliation:
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan. jabe@nch.go.jp
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Child, Preschool
Female
Gene Expression Profiling
Granulocyte Colony-Stimulating Factor / blood*
Humans
Immunoglobulin G / administration & dosage
Immunoglobulins, Intravenous / administration & dosage
Infant
Isoantigens / blood
Male
Membrane Glycoproteins / blood
Mucocutaneous Lymph Node Syndrome / blood*
Predictive Value of Tests
Receptors, Cell Surface / blood
Treatment Failure
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CD177 protein, human; 0/Immunoglobulin G; 0/Immunoglobulins, Intravenous; 0/Isoantigens; 0/Membrane Glycoproteins; 0/Receptors, Cell Surface; 143011-72-7/Granulocyte Colony-Stimulating Factor

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