Document Detail


Elevated ghrelin level in women of normal weight with amenorrhea is related to disordered eating.
MedLine Citation:
PMID:  18001718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether women of normal weight with hypothalamic amenorrhea have elevated ghrelin levels when compared with controls matched for metabolic parameters and whether this elevation is related to disordered eating patterns. DESIGN: Controlled clinical study. SETTING: Healthy volunteers in an academic research environment. PATIENT(S): Twelve subjects of normal weight with functional hypothalamic amenorrhea, 22 exercising controls, and 5 sedentary controls. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Ghrelin level and eating behavior. RESULT(S): The group with functional hypothalamic amenorrhea did not differ from the exercising control group or the sedentary control group with respect to body weight, body fat, and leptin levels. However, ghrelin level showed a significant positive correlation with Eating Attitudes Test (EAT)-40 scores (r = 0.475) at an EAT score > or =10 in all three groups. Eighty-three percent of patients with functional hypothalamic amenorrhea had EAT-40 levels >10. CONCLUSION(S): Elevated EAT scores associated with high ghrelin level may represent dietary behaviors that perpetuate reproductive dysfunction. Thus ghrelin may act as a restraining metabolic signal preventing a return to cyclicity in women with disordered eating and of normal weight and body fat.
Authors:
Lisa F Schneider; Sara E Monaco; Michelle P Warren
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-11-14
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-01     Completed Date:  2008-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology and Medicine, St. Luke's-Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. ls2086@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amenorrhea / blood*,  etiology,  physiopathology
Body Weight*
Case-Control Studies
Eating Disorders / blood,  complications*,  physiopathology
Exercise
Feeding Behavior*
Female
Ghrelin / blood*
Humans
Up-Regulation
Grant Support
ID/Acronym/Agency:
R01 HD36444-01-5/HD/NICHD NIH HHS; R01HD-2217101-07/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Ghrelin

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