Document Detail


Elevated gastrin-releasing peptide receptor mRNA expression in buccal mucosa: association with head and neck squamous cell carcinoma.
MedLine Citation:
PMID:  22431275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Expression of gastrin-releasing peptide receptor (GRPR) is elevated in mucosa adjacent to head and neck squamous cell carcinoma (HNSCC) compared with mucosa from cancer-free controls, suggesting elevated GRPR expression may indicate presence of HNSCC.
METHODS: We measured GRPR mRNA levels in histologically normal buccal mucosa from 65 surgical patients with HNSCC and 75 cancer-free control subjects using quantitative polymerase chain reaction (PCR). We tested for association between GRPR expression and HNSCC and evaluated differences in patient progression-free survival (PFS).
RESULTS: Buccal GRPR expression was higher in cases but not controls who were active smokers (p = .04). High GRPR expression was associated with HNSCC (odds ratio [OR] = 3.55; 95% confidence interval [CI] = 1.15-10.93), even after adjustment for age, sex, tobacco use, and sample storage time. PFS did not differ between patients with HNSCC with high versus low GRPR expression (p = .22).
CONCLUSION: Elevated buccal GRPR expression was significantly associated with HNSCC independent of known risk factors but was not an indicator of disease prognosis.
Authors:
Ann Marie Egloff; Xuwan Liu; Autumn L Gaither Davis; Brian K Trevelline; Marike Vuga; Jill M Siegfried; Jennifer R Grandis
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-03-20
Journal Detail:
Title:  Head & neck     Volume:  35     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-23     Completed Date:  2013-08-07     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Carcinoma, Squamous Cell / genetics*,  pathology
Case-Control Studies
Cohort Studies
Disease-Free Survival
Female
Gene Expression Regulation, Neoplastic*
Head and Neck Neoplasms / genetics*,  mortality,  pathology
Humans
Logistic Models
Male
Middle Aged
Mouth Mucosa / metabolism,  pathology*
Multivariate Analysis
Prognosis
RNA, Messenger / analysis,  genetics
ROC Curve
Real-Time Polymerase Chain Reaction
Receptors, Bombesin / genetics*
Reference Values
Risk Assessment
Sensitivity and Specificity
Survival Analysis
Grant Support
ID/Acronym/Agency:
K07-CA137140/CA/NCI NIH HHS; P50 CA090440/CA/NCI NIH HHS; P50 CA097190/CA/NCI NIH HHS; P50-CA090440/CA/NCI NIH HHS; P50-CA097190/CA/NCI NIH HHS; R01 CA098372/CA/NCI NIH HHS; R01-CA098372/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Bombesin
Comments/Corrections

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