Document Detail

Elevated folate levels in amniotic fluid after oral supplementation.
MedLine Citation:
PMID:  2379664     Owner:  NLM     Status:  MEDLINE    
During oral supplementation of 5 mg folic acid and 1 microgram vitamin B12, the daily folate levels in plasma, red cells and midtrimester amniotic fluid were significantly higher in ten pregnant women during the 15th-18th week of menstrual age as compared to ten non-supplemented women serving as controls. In the control group as well as in the supplemented group, the folate concentrations in amniotic fluid were found to be lower than in the corresponding maternal plasma and red cells. Of all women investigated there was a significant positive correlation between maternal plasma folate concentrations and amniotic fluid levels (r = 0.72, p less than 0.001) and no correlation between red cell folate concentrations and amniotic fluid levels (r = 0.30, p = 0.22). Oral supplementation of vitamin B12 did not elevate maternal blood concentrations and amniotic fluid levels. Vitamin B12 levels in amniotic fluid in this group and controls were always higher than in plasma. These data suggest that the orally administrated dosages of folic acid unlike those of vitamin B12 augment both plasma, red cells and amniotic fluid levels.
R P Steegers-Theunissen; E A Steegers; R de Boer; C M Thomas; M D Kloosterman; T K Eskes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  36     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-09-13     Completed Date:  1990-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  283-91     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University Hospital Nijmegen, The Netherlands.
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MeSH Terms
Administration, Oral
Amniotic Fluid / metabolism*
Erythrocytes / metabolism
European Continental Ancestry Group
Folic Acid / metabolism*
Maternal-Fetal Exchange
Plasma / metabolism
Pregnancy Trimester, Second
Vitamin B 12 / metabolism*
Reg. No./Substance:
59-30-3/Folic Acid; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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