| Elevated extracellular levels of glutamate, aspartate and gamma-aminobutyric acid within the intraoperative, spontaneously epileptiform human hippocampus. | |
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MedLine Citation:
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PMID: 12742599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report preliminary results from four patients subjected to hippocampal electrocorticography and microdialysis during temporal lobe epilepsy surgery. In two cases, spontaneously vigorous hippocampal epileptiform activity (EA) was identified; basal dialysate levels for hippocampal glutamate, aspartate, and gamma-aminobutyric acid ranged from approximately 23- to 84-fold, 19- to 33-fold and 10- to 34-fold higher, respectively, compared to the two cases of minimal hippocampal EA. These findings represent the first intraoperative evidence of elevated extracellular levels of neuroactive amino acids within the spontaneously epileptiform human hippocampus. |
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Authors:
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P M Thomas; J P Phillips; N Delanty; W T O'Connor |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsy research Volume: 54 ISSN: 0920-1211 ISO Abbreviation: Epilepsy Res. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-05-13 Completed Date: 2003-07-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 73-9 Citation Subset: IM |
Affiliation:
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The National Department of Neurosurgery, Beaumont Hospital, Dublin, Ireland. pthomasmd@softhome.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, General Aspartic Acid / metabolism* Electroencephalography Epilepsy, Temporal Lobe / metabolism*, surgery* Female Glutamic Acid / metabolism* Hippocampus / metabolism*, surgery* Humans Intraoperative Period Male gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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56-12-2/gamma-Aminobutyric Acid; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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