Document Detail


Elevated expression of jun and fos-related proteins in transplanted striatal neurons.
MedLine Citation:
PMID:  1782549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The basal expression of the immediate-early gene protein products fos, fos-related antigens (FRA's), jun and krox-24 was examined using immunocytochemical methods in intrastriatal grafts derived from fetal striatal primordia. Whereas very few, if any, normal adult striatal neurons expressed jun, many neurons in the striatal graft expressed jun at high levels. FRA's, but not fos, were also occasionally induced in some grafted striata. krox-24 was expressed in normal adult striatal neurons, and to a lesser extent in transplanted striatal neurons. These results show that neurons of intrastriatal grafts express jun at substantially higher levels than host striatal neurons, and this may be related to the previously reported increased transcription of neuropeptides in striatal grafts, and/or to the possible failure of transplanted neurons to fully establish normal connections with the host tissue.
Authors:
M Dragunow; R L Faull; H J Waldvogel; M N Williams; J Leah
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  558     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-03-17     Completed Date:  1992-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  321-4     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Auckland, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Tissue Transplantation
Corpus Striatum / cytology,  metabolism*
DNA-Binding Proteins / biosynthesis,  genetics
Early Growth Response Protein 1
Fetal Tissue Transplantation
Gene Expression Regulation*
Genes, fos
Immediate-Early Proteins*
Male
Neurons / metabolism*
Proto-Oncogene Proteins c-fos / genetics*
Proto-Oncogene Proteins c-jun / genetics*
Rats
Rats, Inbred Strains
Transcription Factors / biosynthesis,  genetics
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Early Growth Response Protein 1; 0/Egr1 protein, rat; 0/Immediate-Early Proteins; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factors

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