Document Detail


Elevated expression of the genes for transforming growth factor-beta 1 and type VI collagen in diffuse fasciitis associated with the eosinophilia-myalgia syndrome.
MedLine Citation:
PMID:  1702819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Full-thickness skin biopsies obtained from four patients with rapidly progressive diffuse fasciitis associated with the Eosinophilia-Myalgia syndrome (EMS) were examined for the expression of transforming growth factor-beta 1 (TGF-beta 1), type VI collagen, and fibronectin genes employing immunohistochemistry and in situ hybridizations. The immunohistochemical studies demonstrated increased deposition of TGF-beta, type VI collagen, and fibronectin epitopes in the extracellular matrix of the fascia in comparison to the adjacent dermis in the same specimens. Increased levels of type VI collagen mRNA, as evidenced by positive in situ hybridization signals with an alpha 2(VI) collagen cDNA, were also found in the fascia in comparison with the dermis. In situ hybridizations of affected fascia with a human sequence-specific TGF-beta 1 cDNA demonstrated numerous fibroblasts displaying positive hybridization signals indicative of high levels of transcripts for this cytokine. In contrast, no hybridization signal for TGF-beta 1 was detected in fibroblasts in the adjacent dermis. These findings suggest that TGF-beta 1 may play an important role in the development of the connective tissue alterations present in EMS-associated diffuse fasciitis.
Authors:
J Peltonen; J Varga; S Sollberg; J Uitto; S A Jimenez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  96     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-02-20     Completed Date:  1991-02-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20-5     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Jefferson Medical College, Philadelphia, Pennsylvania.
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MeSH Terms
Descriptor/Qualifier:
Aged
Collagen / analysis,  genetics*
Eosinophilia / chemically induced,  genetics*,  pathology
Epitopes / analysis
Fasciitis / genetics*,  pathology
Female
Fibronectins / analysis
Fluorescent Antibody Technique
Gene Expression
Humans
Male
Middle Aged
Muscles / drug effects
Nucleic Acid Hybridization
Pain / chemically induced*
Skin / metabolism,  pathology
Syndrome
Transforming Growth Factor beta / analysis,  genetics*
Tryptophan / adverse effects*
Grant Support
ID/Acronym/Agency:
AR 19101/AR/NIAMS NIH HHS; AR 35297/AR/NIAMS NIH HHS; GM 28833/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Epitopes; 0/Fibronectins; 0/Transforming Growth Factor beta; 73-22-3/Tryptophan; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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