| Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis. | |
| | |
MedLine Citation:
|
PMID: 18090274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Non-Hodgkin's B cell lymphoma (NHL) is a common cancer in HIV infection. Many NHL are thought to result from errors in class switch recombination and/or somatic hypermutation, processes that occur in germinal center B cells, and require the activity of activation induced cytidine deaminase (AID). Since NHL is a common cancer in HIV infection, and expression of AID could contribute to the development of NHL, we hypothesized that AID expression would be elevated in those who went on to develop AIDS-associated NHL (AIDS-NHL). AID mRNA levels were measured by TaqMan RT-PCR in peripheral blood mononuclear cells, obtained prior to AIDS-NHL diagnosis, from 16 HIV-infected subjects who developed AIDS-NHL, and from control subjects (AIDS but no NHL, and HIV-negative subjects). PBMC AID expression was markedly elevated in those who developed AIDS-NHL, when compared to AIDS and HIV-negative controls. Additionally, AID expression was seen to differ depending on NHL subtype, with the highest levels of expression seen in those who developed Burkitt's lymphoma. |
| | |
Authors:
|
Marta Epeldegui; Elizabeth Crabb Breen; Yee Ping Hung; W John Boscardin; Roger Detels; Otoniel Martínez-Maza |
Related Documents
:
|
2997554 - Acquired immune deficiency syndrome. a perspective for the medical practitioner. 1733634 - Anti-neutrophil cytoplasmic autoantibodies in patients with symptomatic hiv infection. 9567324 - Musculoskeletal complications of the patient with acquired immunodeficiency syndrome (a... 10104894 - Southern calif. providers launch campaign to test transfusion recipients for aids virus. 12569034 - Intergenerational communication: fundamental but under-exploited theory for speech and ... 2880354 - The invasion, persistence and spread of infectious diseases within animal and plant com... |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: AIDS (London, England) Volume: 21 ISSN: 0269-9370 ISO Abbreviation: AIDS Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2007-12-19 Completed Date: 2008-03-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8710219 Medline TA: AIDS Country: England |
Other Details:
|
Languages: eng Pagination: 2265-70 Citation Subset: IM; X |
Affiliation:
|
Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Public Health, Los Angeles, California 90095, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult B-Lymphocytes / enzymology* California Case-Control Studies Cell Transformation, Viral Cohort Studies Cytidine Deaminase / genetics* Enzyme Induction Gene Expression Regulation, Viral* Humans Lymphocyte Activation Lymphoma, AIDS-Related / enzymology* Lymphoma, B-Cell / enzymology* Male RNA, Viral / blood Reverse Transcriptase Polymerase Chain Reaction Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
|
AI28697/AI/NIAID NIH HHS; CA57152/CA/NCI NIH HHS; CA73475/CA/NCI NIH HHS; CA96888/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/RNA, Viral; EC 3.5.4.5/Cytidine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Scale-up of HIV care and treatment: can it transform healthcare services in resource-limited setting...
Next Document: Long-term HIV-1 infection of neural progenitor populations.