| Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta. | |
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MedLine Citation:
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PMID: 15809094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In early pregnancy, placental trophoblast cells rapidly grow and invade into maternal uterine tissue. N-Acetylglucosaminyltransferase V (GnT-V) and its product, beta1-6-GlcNAc branching glycan, are known to correlate with tumor invasion and metastasis. Since the placentation process resembles invasion of cancer cells, we examined the expression of beta1-6-GlcNAc branching glycan and GnT-V in human placenta. Placentas derived from the first trimester contained a larger amount of beta1-6-GlcNAc branching glycan, detected by leukoagglutinating phytohemagglutinin lectin blotting, than those at term. Immunohistochemical study revealed that beta1-6-GlcNAc branching glycans and GnT-V protein were localized in the trophoblast layer. Both protein expression and the enzyme activity of GnT-V in first trimester placentas were higher than those at term. These results suggest that GnT-V would contribute to placentation in the early phase of pregnancy, possibly regulating the process of invasion of trophoblast cells. |
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Authors:
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Mari Tomiie; Shigeyuki Isaka; Eiji Miyoshi; Naoyuki Taniguchi; Tadashi Kimura; Kazuhide Ogita; Tateki Tsutsui; Koichiro Shimoya; Takatoshi Nakagawa; Akihiro Kondo; Masayasu Koyama; Yuji Murata |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 330 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-05 Completed Date: 2005-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 999-1004 Citation Subset: IM |
Affiliation:
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Division of Obstetrics and Gynecology, Department of Specific Organ Regulation, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Agglutinins
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chemistry,
pharmacology Blotting, Western Female Gene Expression Regulation, Developmental* Humans Immunohistochemistry N-Acetylglucosaminyltransferases / metabolism* Phytohemagglutinins / chemistry, pharmacology Placenta / cytology, enzymology* Pregnancy Pregnancy Trimester, First / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Agglutinins; 0/Phytohemagglutinins; EC 2.4.1.-/N-Acetylglucosaminyltransferases; EC 2.4.1.155/alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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