Document Detail

Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta.
MedLine Citation:
PMID:  15809094     Owner:  NLM     Status:  MEDLINE    
In early pregnancy, placental trophoblast cells rapidly grow and invade into maternal uterine tissue. N-Acetylglucosaminyltransferase V (GnT-V) and its product, beta1-6-GlcNAc branching glycan, are known to correlate with tumor invasion and metastasis. Since the placentation process resembles invasion of cancer cells, we examined the expression of beta1-6-GlcNAc branching glycan and GnT-V in human placenta. Placentas derived from the first trimester contained a larger amount of beta1-6-GlcNAc branching glycan, detected by leukoagglutinating phytohemagglutinin lectin blotting, than those at term. Immunohistochemical study revealed that beta1-6-GlcNAc branching glycans and GnT-V protein were localized in the trophoblast layer. Both protein expression and the enzyme activity of GnT-V in first trimester placentas were higher than those at term. These results suggest that GnT-V would contribute to placentation in the early phase of pregnancy, possibly regulating the process of invasion of trophoblast cells.
Mari Tomiie; Shigeyuki Isaka; Eiji Miyoshi; Naoyuki Taniguchi; Tadashi Kimura; Kazuhide Ogita; Tateki Tsutsui; Koichiro Shimoya; Takatoshi Nakagawa; Akihiro Kondo; Masayasu Koyama; Yuji Murata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  330     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-05     Completed Date:  2005-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  999-1004     Citation Subset:  IM    
Division of Obstetrics and Gynecology, Department of Specific Organ Regulation, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan.
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MeSH Terms
Agglutinins / chemistry,  pharmacology
Blotting, Western
Gene Expression Regulation, Developmental*
N-Acetylglucosaminyltransferases / metabolism*
Phytohemagglutinins / chemistry,  pharmacology
Placenta / cytology,  enzymology*
Pregnancy Trimester, First / metabolism*
Reg. No./Substance:
0/Agglutinins; 0/Phytohemagglutinins; EC 2.4.1.-/N-Acetylglucosaminyltransferases; EC,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase

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