| Elevated exhaled nitric oxide in patients with hepatopulmonary syndrome. | |
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MedLine Citation:
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PMID: 8620957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypoxaemia of hepatopulmonary syndrome, seen in severe chronic liver dysfunction, occurs as a result of precapillary pulmonary arterial dilatation and arteriovenous communications. These abnormalities contribute to the mismatch between ventilation and perfusion, and the right to left blood flow shunting. Nitric oxide (NO) is a powerful vasodilator concerned with the regulation of pulmonary vascular tone in man. Using a chemiluminescence analyser, we have measured endogenously produced NO in the exhaled air of three patients with the hepatopulmonary syndrome, six normoxaemic cirrhotic patients and six healthy volunteers. The subjects breathed NO-free air throughout the measurements. The molar rate of production of exhaled NO was raised almost threefold in the patients with hepatopulmonary syndrome compared with normal volunteers and with normoxaemic cirrhotic patients. Hypoxia per se, achieved in the normal volunteers by breathing a hypoxic gas mixture, reduced rather than increased the exhaled NO. One hepatopulmonary syndrome patient received an orthotopic liver transplant and achieved normoxaemia after 3 months. The exhaled NO also returned to normal. Increased pulmonary production of NO could contribute to the development of the hepatopulmonary syndrome. |
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Authors:
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G Cremona; T W Higenbottam; V Mayoral; G Alexander; E Demoncheaux; C Borland; P Roe; G J Jones |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 8 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-06-14 Completed Date: 1996-06-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 1883-5 Citation Subset: IM |
Affiliation:
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Dept of Respiratory Physiology, Addenbrookes Hospital, Cambridge, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
/
etiology,
metabolism* Blood Gas Analysis Breath Tests Humans Liver Cirrhosis / complications*, surgery Liver Transplantation Lung Diseases / complications*, metabolism Male Nitric Oxide / metabolism* Syndrome |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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