| Elevated exhaled carbon monoxide concentration in hemoglobinopathies and its relation to red blood cell transfusion therapy. | |
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MedLine Citation:
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PMID: 20201692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, the authors examined a possible role of measurements of end-tidal carbon monoxide (CO), corrected for inhaled CO (ETCOc), as a noninvasive screening tool for hemoglobinopathies and as an indicator for when transfusions would be required in patients receiving chronic transfusions. ETCOc measurements were obtained in subjects with sickle cell disease (n = 18), thalassemia (n = 21), and healthy controls (n = 62). ETCOc values less than 3 parts per million (ppm) yielded a positive predictive value of 93% and negative predictive value of 94% in identifying hemoglobinopathies. Subsequently, 7 subjects with thalassemia had laboratory parameters and ETCOc measured over 2 transfusion cycles. ETCOc values were 4.90 +/- 0.32 ppm (mean +/- SD), with 89% of values being above normal (>or=3 ppm). Pretransfusion ETCOc levels significantly correlated with pretransfusion reticulocyte count (r = .96, P <.001), but not with pretransfusion hemoglobin (r = .44, P = .16) or pretransfusion soluble transferrin receptors (sTfR, r = .52, P = .10). In conclusion, we found that patients with hemoglobinopathies have ETCOc values above the range for healthy controls and ETCOc measurements can be used as an adjunct to hemoglobin measurements to determine the proper timing of transfusions. |
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Authors:
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Ellen Butensky James; Hendrik J Vreman; Ronald J Wong; David K Stevenson; Elliott Vichinsky; Laurie Schumacher; Judith Y Hall; Julie Simon; Daniel W Golden; Paul Harmatz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric hematology and oncology Volume: 27 ISSN: 1521-0669 ISO Abbreviation: Pediatr Hematol Oncol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700164 Medline TA: Pediatr Hematol Oncol Country: England |
Other Details:
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Languages: eng Pagination: 112-21 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Children's Hospital & Research Center Oakland, Oakland, California 94609, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia, Sickle Cell / diagnosis, therapy Breath Tests Carbon Monoxide / analysis*, metabolism Child Child, Preschool Cross-Sectional Studies Erythrocyte Transfusion* Exhalation / physiology* Female Hemoglobinopathies / diagnosis*, therapy* Humans Longitudinal Studies Male Predictive Value of Tests Thalassemia / diagnosis, therapy Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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HL-20985/HL/NHLBI NIH HHS; M01-RR00070/RR/NCRR NIH HHS; M01-RR01271-16/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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