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Elevated energy coupling and aerobic capacity improves exercise performance in endurance trained elderly.
MedLine Citation:
PMID:  23204291     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Increased VO2max, mitochondrial capacity and energy coupling efficiency are reported after endurance training (ET) in adult subjects. Here we test whether leg exercise performance (power output of the legs, Pmax, at VO2max) reflects these improvements with ET in the elderly. Fifteen male and female subjects were endurance trained for a 6-month program with 13 subjects (69.5 ± 1.2 yrs, range: 65-80 yrs; males: n =7, females, n =6) completing the study. This training significantly improved Pmax (17%, P=0.003), VO2max (5.4%, P=0.021) and the increment in VO2 above resting (VO2 m-r= VO2max-VO2rest, 9%; P<0.02). In addition, evidence of improved energy coupling came from elevated leg power output per VO2 at the aerobic capacity ((Pmax/(VO2m-r), P=0.02) and during submaximal exercise in the ramp test as measured by delta efficiency (P/VO2, P=0.04). No change was found in blood lactate, muscle glycolysis or fiber type composition as previously reported in this group (Jubrias et al. J Appl Physiol. 90:1663, 2001). The rise in Pmax paralleled the improvement in muscle oxidative phosphorylation capacity (ATPmax) reported in these subjects. In addition, the greater exercise energy coupling ((Pmax /VO2m-r) and delta efficiency) was accompanied by increased mitochondrial energy coupling as measured by elevated ATP production per mitochondrial content reported in these subjects. These results suggest that leg exercise performance benefits from elevations in energy coupling and oxidative phosphorylation capacity at both the whole-body and muscle levels that accompany endurance training in the elderly.
Authors:
Kevin Conley; Sharon Jubrias; Elaine Cress; Peter Esselman
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-30
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 University of Washington;
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