Document Detail

Elevated corticosterone in the dorsal hindbrain increases plasma norepinephrine and neuropeptide Y, and recruits a vasopressin response to stress.
MedLine Citation:
PMID:  24829502     Owner:  NLM     Status:  Publisher    
Repeated stress and chronically elevated glucocorticoids cause exaggerated cardiovascular responses to novel stress, elevations in baseline blood pressure and increased risk for cardiovascular disease. We hypothesized that elevated corticosterone (Cort) within the dorsal hindbrain (DHB): (1) enhances arterial pressure and neuroendocrine responses to novel and repeated restraint stress, (2) increases c-Fos expression in regions of the brain involved in sympathetic stimulation during stress and, (3) recruits a vasopressin-mediated blood pressure response to acute stress. Small pellets made of 10% Cort were implanted on the surface of the DHB in male Sprague-Dawley rats. Blood pressure was measured by radiotelemetry. Cort concentration was increased in the DHB in Cort-treated compared with Sham-treated rats (60±15 vs. 14±2 ng Cort/g of tissue, P<0.05). DHB Cort significantly increased the integrated arterial pressure response to 60 min of restraint stress on days 6, 13 and 14 following pellet implantation (e.g. 731±170 vs. 1204±68 mmHg/60 min in Sham- vs. Cort-treated rats, day 6, P<0.05). Cort also increased baseline blood pressure by day 15 (99±2 vs. 108±3 mmHg for Sham- vs. Cort-treated rats, P<0.05) and elevated baseline plasma norepinephrine and neuropeptide Y concentrations. Cort significantly enhanced stress-induced c-Fos expression in vasopressin-expressing neurons in the paraventricular nucleus of the hypothalamus, and blockade of peripheral vasopressin V1 receptors attenuated the effect of DHB Cort to enhance the blood pressure response to restraint. These data indicate that glucocorticoids act within the DHB to produce some of the adverse cardiovascular consequences of chronic stress in part by a peripheral vasopressin-dependent mechanism.
Daisy L Daubert; Benjamin M Looney; Rebekah R Clifton; Jake N Cho; Deborah A Scheuer
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-14
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.
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