| Elevated coronary sinus pressure does not alter myocardial blood flow or left ventricular contractile function in mature sheep. Implications after the Fontan operation. | |
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MedLine Citation:
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PMID: 3343858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypothesis that elevation of coronary sinus pressure affects coronary blood flow and ventricular function was tested in this study of seven adult ewes placed under pentobarbital anesthesia. Coronary sinus pressure was elevated by partial balloon occlusion. Right atrial, left atrial, and aortic mean pressures and rate of rise of left ventricular pressure were measured. Coronary blood flow was determined with radioactive microspheres. Studies were performed at control and at moderate (15 to 20 mm Hg) and marked (30 to 35 mm Hg) elevation of coronary sinus mean pressures. Despite increase of coronary sinus pressure from a control value of 2 mm Hg +/- 1 to levels of 19 mm Hg +/- 1 and 34 mm Hg +/- 1, no significant changes were observed in right atrial, left atrial, or aortic mean pressure or rate of rise of left ventricular pressure. Both endocardial and epicardial blood flows were unaffected. The endocardial/epicardial flow ratio at moderate coronary sinus pressure elevation was significantly increased, which suggested local subendocardial vasodilation in the absence of changes in transmural perfusion. The findings suggest that isolated increase in coronary sinus pressure is not a major determinant of myocardial blood flow or ventricular performance in the normal ewe. |
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Authors:
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K E Ward; D J Fisher; L Michael |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 95 ISSN: 0022-5223 ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-04-07 Completed Date: 1988-04-07 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 511-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics and Medicine, Baylor College of Medicine, Houston, Texas. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Coronary Circulation* Coronary Vessels / physiology*, surgery Heart Atria / surgery Myocardial Contraction* Postoperative Complications / physiopathology Sheep |
| Comments/Corrections | |
Comment In:
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J Thorac Cardiovasc Surg. 1989 Oct;98(4):634-6
[PMID:
2796372
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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