Document Detail

Elevated copper and lowered zinc in the placentae of pre-eclamptics.
MedLine Citation:
PMID:  3978817     Owner:  NLM     Status:  MEDLINE    
Selected cations (Ca, Co, Cu, Mg, Zn, Si, and K) were determined in the placentae of 18 women. Between pre-eclamptic and normal subjects there were significant (p less than 0.05) differences in copper and zinc concentrations and borderline significant differences in cobalt concentration. In the placentae of the ten women with a normal pregnancy, the average concentrations of copper and zinc were 53 and 192 micrograms atoms/kg placenta, respectively. In the placentae of 8 women with pre-eclampsia, the concentrations were 124 and 134 micrograms atoms/kg placenta for copper and zinc, respectively. Elevation of copper and decrease in zinc may be an exaggeration of normal pregnancy physiology that occurs in pre-eclampsia.
M H Brophy; N F Harris; I L Crawford
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  145     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-05-15     Completed Date:  1985-05-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
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MeSH Terms
Cations / analysis
Copper / metabolism*
Placenta / metabolism*
Pre-Eclampsia / metabolism*
Zinc / deficiency,  metabolism*
Reg. No./Substance:
0/Cations; 7440-50-8/Copper; 7440-66-6/Zinc

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