| Elevated concentrations of prorenin and renin in amniotic fluid of women with chorioamnionitis. | |
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MedLine Citation:
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PMID: 9134509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to determine the concentrations of prorenin and renin in amniotic fluid of women under various physiologic and pathologic conditions. METHODS: Amniotic fluid was collected from women with chorioamnionitis treated in the Labor and Delivery Unit, University of Utah Medical Center, and from gestation-matched control women with preterm labor who were delivered within 1 week and later than 1 week and at term in labor or not in labor. Prorenin and renin concentrations were measured in these fluids by a direct immunoradiometric assay. RESULTS: Large amounts of prorenin and renin were detected in all samples with 85% to 95% in the form of prorenin. Concentrations of both prorenin and renin were significantly higher in the amniotic fluid of women with chorioamnionitis than in the amniotic fluid of control women. There were no other significant differences between the groups. CONCLUSIONS: Our data indicate that amniotic fluid concentrations of renin and prorenin are elevated in women with clinically evident chorioamnionitis. We suggest that these elevations reflect a possible role for renin and prorenin in the pathophysiologic process of intrauterine infection-associated preterm labor. |
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Authors:
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M D Mitchell; C Hunter; D J Dudley; M W Varner |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 17 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 1997 Mar-Apr |
Date Detail:
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Created Date: 1997-07-16 Completed Date: 1997-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 116-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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chemistry* Chorioamnionitis / diagnosis, enzymology* Enzyme Precursors / analysis, metabolism* Female Humans Labor, Obstetric Obstetric Labor, Premature Pregnancy Pregnancy Outcome* Radioimmunoassay Renin / analysis, metabolism* Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Precursors; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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