| Elevated concentrations of oxidized lipoprotein(a) are associated with the presence and severity of acute coronary syndromes. | |
| | |
MedLine Citation:
|
PMID: 19646429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate possible mechanisms and association of increased oxidized Lp(a) [ox-Lp(a)] levels with presence and extent of acute coronary syndromes (ACS). METHODS: Ox-Lp(a) levels were studied in 96 patients with ACS, 89 patients with stable coronary artery disease (CAD), and 100 control subjects. RESULTS: Compared to control, ox-Lp(a) levels increased in stable CAD patients (P<0.001), and especially in ACS (P<0.001) (ACS, 16.29+/-13.80 microg/ml; stable CAD, 10.04+/-10.32 microg/ml; control, 7.10+/-9.16 microg/ml). The ratio of ox-Lp(a) to Lp(a) was higher in the ACS than those in the stable CAD (P<0.05) and control (P<0.001). Ox-Lp(a) levels were found associated with a graded increase in extent of angiographically documented CAD in the ACS (R=0.275, P=0.007), while not in the stable CAD (R=0.090, P=0.402). Multiple linear regression analysis found ox-Lp(a) (beta=0.271, P=0.019), age (beta=0.244, P=0.038) and TG (beta=0.213, P=0.070) accounted for 11.1% of the variation in the extent of angiographically documented CAD in ACS patients; Lp(a) (beta=0.415, P=0.000) and extent of CAD (beta=0.193, P=0.071) accounted for 21.5% of that in ox-Lp(a) levels. CONCLUSION: Elevated ox-Lp(a) levels are associated with presence and severity of ACS, and may be useful for identification of patients with ACS. |
| | |
Authors:
|
Jun-jun Wang; Chun-ni Zhang; Yang Meng; Ai-zhong Han; Jian-bin Gong; Ke Li |
Related Documents
:
|
16266039 - Prediction of coronary artery disease in patients undergoing carotid endarterectomy. 11125869 - Independent determinants of the efficacy of nitrate therapy. 22737569 - Relation between body humors and hypercholesterolemia: an iranian traditional medicine ... 18278189 - Increased thrombin generation after acute versus chronic coronary disease as assessed b... 20140679 - Serum profiles of monocyte chemoattractant protein-1 as a biomarker for patients recove... 1809619 - Intracoronary streptokinase in unstable angina: a prospective randomised study. 12381799 - Use of the tissue stress model as a paradigm for developing an examination and manageme... 20576109 - Alterations of matrix metalloproteinases in the healthy elderly with increased risk of ... 8946279 - Antiplatelet glycoprotein autoantibodies in patients with autoimmune diseases with and ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-29 |
Journal Detail:
|
Title: Clinica chimica acta; international journal of clinical chemistry Volume: 408 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-09-14 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 79-82 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China. wangjj6@jlonline.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Coronary Syndrome
/
complications,
metabolism*,
pathology*,
radiography Angiography Coronary Artery Disease / complications, radiography Female Humans Lipoprotein(a) / metabolism* Male Middle Aged Oxidation-Reduction |
| Chemical | |
Reg. No./Substance:
|
0/Lipoprotein(a) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heparin interference in the cerebrospinal fluid protein assay measured with a pyrogallol red-molybda...
Next Document: Differential expression profiling of microRNAs and their potential involvement in renal cell carcino...