Document Detail

Elevated concentration of 5-hydroxytryptamine in ultrafiltrate of human liver vein plasma after infusion of amino acids.
MedLine Citation:
PMID:  3227956     Owner:  NLM     Status:  MEDLINE    
Intragastric infusion of amino acids causes the release from the liver of a factor with stimulatory effect on smooth muscle. The effect of liver vein plasma ultrafiltrate was tested on isolated preparations of rat fundus. The ultrafiltrates collected after amino acid infusion had a 3-5 times higher stimulatory effect on smooth muscle contraction than those collected from control plasma. The active principle was isolated, purified by different chromatographic procedures and identified as 5-hydroxytryptamine (serotonin). No other compound with contractile effect on smooth muscle was detected.
L Zimmerman; A Alvestrand; J Bergström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  134     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-04-06     Completed Date:  1989-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  399-403     Citation Subset:  IM    
Department of Renal Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.
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MeSH Terms
Amino Acids / administration & dosage*
Hepatic Veins
Muscle Contraction / drug effects
Muscle, Smooth / drug effects
Serotonin / isolation & purification*,  pharmacology
Reg. No./Substance:
0/Amino Acids; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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