Document Detail


Elevated circulating levels of copper and nickel are found in elderly subjects with left ventricular hypertrophy.
MedLine Citation:
PMID:  23079738     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Identified risk factors for left ventricular hypertrophy (LVH) are hypertension, diabetes and obesity. However, since these risk factors only explain a part of the variation in left ventricular mass, we investigated if trace and heavy metals might also play a role in LVH. In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, left ventricular mass index (LVMI) and relative wall thickness (RWT) were determined by echocardiography together with eleven different trace and heavy metals in 993 subjects aged 70 years. Only copper levels were significantly related to LVMI following adjustment for sex, blood pressure, antihypertensive treatment, diabetes and body mass index (BMI) (p<0.0001). However, both copper (Cu) and nickel (Ni) were related to RWT following adjustment (p<0.0001). When divided into four geometric groups, both Cu and Ni were elevated in subjects with concentric remodelling and concentric LVH, but not in those with eccentric hypertrophy, when compared to subjects with a normal left ventricle. No relationships were found for zinc, aluminium, manganese, molybdenum, mercury, lead, cadmium, cobalt or chromium. Elevated levels of copper and nickel are found in elderly subjects with LVH, especially of the concentric type, following adjustment for known risk factors for LVH.
Authors:
P Monica Lind; Lena Olsén; Lars Lind
Related Documents :
6694328 - Immediate prognosis in acute myocardial infarction: serial changes in immediate mortali...
16169358 - Usefulness of the timi risk index in predicting short- and long-term mortality in patie...
23023228 - Improved agreement between experienced and inexperienced observers using a standardized...
17391108 - Myocardial infarction with normal coronary arteries: a conundrum with multiple aetiolog...
15678458 - Radiofrequency perforation and cutting balloon septoplasty of intact atrial septum in a...
15534058 - Dobutamine stress 99mtc-tetrofosmin quantitative gated spect predicts improvement of ca...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-15
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  -     ISSN:  1090-2414     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, University Hospital, 751 85 Uppsala, Sweden. Electronic address: Monica.Lind@medsci.uu.se.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  [In Process Citation].
Next Document:  Bioaccumulation of heavy metals in water, sediments, aquatic plant and histopathological effects on ...