Document Detail


Elevated cholecystokinin-like activity in the duodenal mucosa in patients with cholecystolithiasis.
MedLine Citation:
PMID:  4024074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cholecystokinin (CCK)-like activities in the duodenal mucosa of the patients with cholecystolithiasis were determined with the bioassay method we established. The results obtained are as follows: The gall bladder of the patients with cholecystolithiasis following oral administration of egg yolk has contraction rates comparable to those of the normal subjects in the control group, whereas the contraction rate of the gall bladder of the patients with cholecystolithiasis following administration of caerulein was markedly lower than that of the normal subjects in the control group. The variations in the contraction of the gall bladder in time lapse following administration of caerulein to the patients with cholecystolithiasis strongly denied the possibility of either insufficient release of CCK or accelerated dissimilation of CCK in those patients. Based on the above findings, it was concluded that the sensitivity of the gall bladder to CCK decreases in the patients with cholecystolithiasis and that, in order to replenish it, the feed-back mechanism reacts to sufficiently promote the production of CCK in the duodenal mucosa. The similar mechanism was noted in the variations of the findings of normal subjects as age advanced.
Authors:
S Kataoka; K Syoji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  145     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-09-19     Completed Date:  1985-09-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  395-402     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Caerulein / diagnostic use
Cholecystography
Cholecystokinin / metabolism*
Cholelithiasis / physiopathology*,  radiography
Duodenum / metabolism*
Egg Yolk
Female
Gallbladder / physiopathology
Humans
Intestinal Mucosa / metabolism*
Kinetics
Male
Middle Aged
Muscle Contraction
Chemical
Reg. No./Substance:
17650-98-5/Caerulein; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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