Document Detail

Elevated cholecystokinin-like activity in the duodenal mucosa in patients with cholecystolithiasis.
MedLine Citation:
PMID:  4024074     Owner:  NLM     Status:  MEDLINE    
Cholecystokinin (CCK)-like activities in the duodenal mucosa of the patients with cholecystolithiasis were determined with the bioassay method we established. The results obtained are as follows: The gall bladder of the patients with cholecystolithiasis following oral administration of egg yolk has contraction rates comparable to those of the normal subjects in the control group, whereas the contraction rate of the gall bladder of the patients with cholecystolithiasis following administration of caerulein was markedly lower than that of the normal subjects in the control group. The variations in the contraction of the gall bladder in time lapse following administration of caerulein to the patients with cholecystolithiasis strongly denied the possibility of either insufficient release of CCK or accelerated dissimilation of CCK in those patients. Based on the above findings, it was concluded that the sensitivity of the gall bladder to CCK decreases in the patients with cholecystolithiasis and that, in order to replenish it, the feed-back mechanism reacts to sufficiently promote the production of CCK in the duodenal mucosa. The similar mechanism was noted in the variations of the findings of normal subjects as age advanced.
S Kataoka; K Syoji
Related Documents :
18645274 - Efficacy of doxazosin in the treatment of acute urinary retention due to benign prostat...
16980734 - Trabeculation of urinary bladder by ultrasound in patients with benign prostatic hyperp...
6244414 - Prophylaxis of bacteriuria during intermittent catheterization of the acute neurogenic ...
16753424 - Modified bladder neck reconstruction in patients with incontinence after staged exstrop...
20090534 - B-type natriuretic peptide in patients undergoing orthopaedic surgery: a prospective co...
24745584 - Trans-oral endoscopic cerclage pharyngoplasty for treatment of velopharyngeal insuffici...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  145     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-09-19     Completed Date:  1985-09-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  395-402     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Caerulein / diagnostic use
Cholecystokinin / metabolism*
Cholelithiasis / physiopathology*,  radiography
Duodenum / metabolism*
Egg Yolk
Gallbladder / physiopathology
Intestinal Mucosa / metabolism*
Middle Aged
Muscle Contraction
Reg. No./Substance:
17650-98-5/Caerulein; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Precancerous lesions of the gallbladder mucosa.
Next Document:  Constant growth of primary school children throughout four seasons of year.