| Elevated cholecystokinin-like activity in the duodenal mucosa in patients with cholecystolithiasis. | |
| | |
MedLine Citation:
|
PMID: 4024074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cholecystokinin (CCK)-like activities in the duodenal mucosa of the patients with cholecystolithiasis were determined with the bioassay method we established. The results obtained are as follows: The gall bladder of the patients with cholecystolithiasis following oral administration of egg yolk has contraction rates comparable to those of the normal subjects in the control group, whereas the contraction rate of the gall bladder of the patients with cholecystolithiasis following administration of caerulein was markedly lower than that of the normal subjects in the control group. The variations in the contraction of the gall bladder in time lapse following administration of caerulein to the patients with cholecystolithiasis strongly denied the possibility of either insufficient release of CCK or accelerated dissimilation of CCK in those patients. Based on the above findings, it was concluded that the sensitivity of the gall bladder to CCK decreases in the patients with cholecystolithiasis and that, in order to replenish it, the feed-back mechanism reacts to sufficiently promote the production of CCK in the duodenal mucosa. The similar mechanism was noted in the variations of the findings of normal subjects as age advanced. |
| | |
Authors:
|
S Kataoka; K Syoji |
Related Documents
:
|
19112944 - Insight into long-term histological, proliferative and apoptotic modifications in ileal... 20566014 - Predictors of early urinary continence after robotic prostatectomy. 1142484 - Exstrophy of the bladder. i. long-term results in a series of 37 cases treated by urete... 21110094 - Injections of botulinum toxin a into the detrusor to treat neurogenic detrusor overacti... 20881514 - Continuous infusion of bupivacaine reduces postoperative morphine use in adolescent idi... 19373484 - Long-term effects of radiofrequency ablation of the soft palate on snoring. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Tohoku journal of experimental medicine Volume: 145 ISSN: 0040-8727 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 1985 Apr |
Date Detail:
|
Created Date: 1985-09-19 Completed Date: 1985-09-19 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 395-402 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Caerulein / diagnostic use Cholecystography Cholecystokinin / metabolism* Cholelithiasis / physiopathology*, radiography Duodenum / metabolism* Egg Yolk Female Gallbladder / physiopathology Humans Intestinal Mucosa / metabolism* Kinetics Male Middle Aged Muscle Contraction |
| Chemical | |
Reg. No./Substance:
|
17650-98-5/Caerulein; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Precancerous lesions of the gallbladder mucosa.
Next Document: Constant growth of primary school children throughout four seasons of year.