Document Detail

Elevated cerebrospinal fluid and serum YKL-40 levels are not associated with symptomatic vasospasm in patients with aneurysmal subarachnoid haemorrhage.
MedLine Citation:
PMID:  18280741     Owner:  NLM     Status:  MEDLINE    
YKL-40 is a newly discovered matrix protein that is thought to be released during the acute stages of inflammation. It has recently been speculated that YKL-40 may serve as a specific serological marker of neutrophil function at the site of tissue inflammation. Our aim was to determine whether the levels of YKL-40 in both the cerebrospinal fluid and sera of 22 patients with aneurysmal subarachnoid haemorrhage were associated with either vasospasm or outcome. The levels were also compared with those of 16 control patients with hydrocephalus. We found that patients with aneurysmal subarachnoid haemorrhage had significantly higher YKL-40 levels in both cerebrospinal fluid and serum than controls. However, elevated YKL-40 levels were not associated with symptomatic vasospasm or 6-month outcome. We show that elevated YKL-40 levels are not correlated with the severity of subarachnoid haemorrhage and cannot be used as a serological marker of inflammation in patients with an aneurysm rupture.
Tibet Kacira; Hakan Hanimoglu; Mine Kucur; Galip Zihni Sanus; Ali Metin Kafadar; Taner Tanriverdi; Mehmet Yasar Kaynar
Publication Detail:
Type:  Journal Article     Date:  2008-02-15
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  15     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-10-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  1011-6     Citation Subset:  IM    
Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Biological Markers / analysis,  blood,  cerebrospinal fluid
Cerebral Arteries / metabolism,  physiopathology
Encephalitis / diagnosis,  immunology,  physiopathology
Glycoproteins / blood*,  cerebrospinal fluid*
Middle Aged
Predictive Value of Tests
Subarachnoid Hemorrhage / blood*,  cerebrospinal fluid*,  complications
Subarachnoid Space / immunology,  metabolism,  physiopathology
Time Factors
Up-Regulation / immunology
Vasospasm, Intracranial / blood*,  cerebrospinal fluid*,  complications
Reg. No./Substance:
0/Biological Markers; 0/CHI3L1 protein, human; 0/Glycoproteins; 0/Lectins

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