Document Detail


Elevated carbohydrate antigen 19-9 (CA 19-9) in patients with Echinococcus infection.
MedLine Citation:
PMID:  11506466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The carbohydrate antigen 19-9 (CA 19-9), a determinant (sialylated lacto-N-fucopentaose 119) of a circulating oligosaccharide antigen, is a frequently used tumor marker. Echinococcus spp. infects humans throughout the world and may be able to synthesize closely related molecules which could interfere with the measurement and interpretation of CA 19-9 concentration. The main objective of the present study was to determine the range of CA 19-9 levels in the sera of patients infected by E. granulosus (cystic hydatide disease; CYSHD) or E. multilocularis (alveolar hydatide disease; ALVHD). Serum samples were collected from patients (aged 10-85 years) over a period of 5 years: from 19 patients with CYSHD and from 20 patients with ALVHD. Infection was confirmed by positive Echinococcus serology and clinical evidence provided by imaging and/or histopathological findings. CA 19-9 was detectable in 13 patients with CYSHD (13.5 +/- 8.5 kU/l) and 13 patients with ALVHD (30.0 +/- 21 kU/l; p < 0.05). Thus ALVHD patients exhibited a significantly higher plasma level of CA 19-9 than CYSHD patients. The serum level of CA 19-9 assessed with an increased cut-off value (> 22 kU/l) was elevated in nine (45%) of 20 ALVHD patients compared to two (11%) of 19 CYSHD patients (p < 0.05). Sera from patients with Echinococcus multilocularis infection contain substances which cross-react with CA 19-9. These substances originate either from the parasite or are synthesized by the host in response to the infection, and possibly bear the Lewis-a antigen or closely related structures which are recognized by anti-CA 19-9 antibodies. Our findings are relevant to the investigation of patients presenting with cystic lesions for which the differential diagnosis includes an infectious or neoplastic origin.
Authors:
M Pfister; B Gottstein; R Kretschmer; T Cerny; A Cerny
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  39     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-08-16     Completed Date:  2002-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  527-30     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Bern, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Antigens, Helminth / blood
CA-19-9 Antigen / blood*
Child
Cross Reactions
Diagnosis, Differential
Echinococcosis / blood,  diagnosis,  immunology*
Echinococcosis, Hepatic / blood,  diagnosis,  immunology*
Echinococcus / immunology
Female
Humans
Lewis Blood-Group System / blood
Liver Diseases / blood,  diagnosis,  immunology
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antigens, Helminth; 0/CA-19-9 Antigen; 0/Lewis Blood-Group System

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