Document Detail


Elevated brachial-ankle pulse wave velocity is associated with left ventricular hypertrophy in hypertensive patients after stroke.
MedLine Citation:
PMID:  20208411     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brachial-ankle pulse wave velocity (baPWV) is widely used as a marker of arterial stiffness, but there are no data regarding the usefulness of measuring baPWV in hypertensive patients after stroke. The purpose of this study was to examine the clinical significance of baPWV by assessing its correlation with echocardiographic parameters in hypertensive patients after stroke. The study enrolled 61 hypertensives after stroke (24 patients with cerebral infarction and 37 with cerebral hemorrhage) and 61 age-matched hypertensives without stroke. Left ventricular (LV) hypertrophy was evaluated by measuring LV mass index (LVMI) and relative wall thickness (RWT), and LV diastolic function was evaluated by measuring peak early mitral annular velocities (E') using echocardiography. Concentric LV hypertrophy showing increased RWT (0.50 +/- 0.12) was observed in hypertensives after stroke, but not in hypertensives without stroke. In hypertensives after stroke, elevated baPWV correlated with age (r = 0.60, p < 0.001), systolic blood pressure (r = 0.56, p < 0.001), increased LVMI (r = 0.47, p < 0.001), and decreased E' (r = -0.40, p = 0.002). Multiple regression analysis showed that age (beta coefficient = 0.43, p < 0.001), systolic blood pressure (beta coefficient = 0.40, p < 0.001), and LVMI (beta coefficient = 0.25, p = 0.008) were independent determinants of elevated baPWV. In conclusion, elevated baPWV is more closely associated with LV hypertrophy than with LV diastolic dysfunction. Elevated baPWV is independently associated with the severity of LV hypertrophy adjusted with systolic blood pressure and age in hypertensive patients after stroke.
Authors:
Hisashi Masugata; Shoichi Senda; Jun Hoshikawa; Koji Murao; Naohisa Hosomi; Hiroyuki Okuyama; Michio Inukai; Takashi Himoto; Yoichi Nakatsuka; Masanobu Imai; Takahisa Noma; Masakazu Kohno; Fuminori Goda
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  220     ISSN:  1349-3329     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-05-18     Revised Date:  2013-01-03    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  177-82     Citation Subset:  IM    
Affiliation:
Department of Integrated Medicine, Kagawa University, Kagawa, Japan. masugata@med.kagawa-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Ankle / blood supply*
Blood Flow Velocity
Blood Pressure / physiology
Brachial Artery / physiology*,  physiopathology
Echocardiography
Female
Humans
Hypertension / physiopathology*
Hypertrophy, Left Ventricular / physiopathology*
Male
Middle Aged
Pulsatile Flow / physiology
Pulse*
Stroke / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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