Document Detail

Elevated arterial cyclic AMP levels during the development of one-kidney, one-clip and DOCA hypertension in rats.
MedLine Citation:
PMID:  2851454     Owner:  NLM     Status:  MEDLINE    
A marked increase in the cyclic AMP content and concentration of the thoracic aorta was detected during the rise in blood pressure produced by one-kidney, one-clip and DOCA hypertension. This alteration was accompanied by the development of vascular hypertrophy and preceded the abnormal increase in DNA content observed in the arterial system during the more chronic stages of the disease. These experiments suggest the participation of cyclic AMP in the development of hypertension vascular growth.
B N Dardik; P M DiBello; R E Chatelain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  158     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-03-17     Completed Date:  1989-03-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Research Department, CIBA-GEIGY Corporation, Summit, NJ 07901.
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MeSH Terms
Aorta, Thoracic / metabolism
Blood Pressure
Cyclic AMP / blood*
DNA / metabolism
Hypertension / etiology,  metabolism*,  physiopathology
Hypertension, Renovascular / etiology,  metabolism,  physiopathology
Reg. No./Substance:
60-92-4/Cyclic AMP; 64-85-7/Desoxycorticosterone; 9007-49-2/DNA

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